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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 6 — Jun. 17, 2008

Adjoint time domain method for fluorescent imaging in turbid media

Vadim Y. Soloviev, Cosimo D’Andrea, Marco Brambilla, Gianluca Valentini, Ralf B. Schulz, Rinaldo Cubeddu, and Simon R. Arridge  »View Author Affiliations

Applied Optics, Vol. 47, Issue 13, pp. 2303-2311 (2008)

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Application of adjoint time domain methods to the inverse problem in 3D fluorescence imaging is a novel approach. We demonstrate the feasibility of this approach experimentally on the basis of a time gating technique completely in the time domain by using a small number of time windows. The evolution of the fluorescence energy density function inside a highly scattering cylinder was reconstructed together with optical parameters. Reconstructed energy density was used in localizing two fluorescent tubes. Relatively accurate reconstruction demonstrates the effectiveness and the potential of the proposed technique.

© 2008 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(290.0290) Scattering : Scattering
(290.7050) Scattering : Turbid media

ToC Category:

Original Manuscript: October 25, 2007
Revised Manuscript: February 5, 2008
Manuscript Accepted: March 27, 2008
Published: April 28, 2008

Virtual Issues
Vol. 3, Iss. 6 Virtual Journal for Biomedical Optics

Vadim Y. Soloviev, Cosimo D'Andrea, Marco Brambilla, Gianluca Valentini, Ralf B. Schulz, Rinaldo Cubeddu, and Simon R. Arridge, "Adjoint time domain method for fluorescent imaging in turbid media," Appl. Opt. 47, 2303-2311 (2008)

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