Chemical imaging with Fourier transform coherent anti-Stokes Raman scattering microscopy
Applied Optics, Vol. 47, Issue 31, pp. 5790-5798 (2008)
http://dx.doi.org/10.1364/AO.47.005790
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Abstract
We report chemical imaging using Fourier transform coherent anti-Stokes Raman scattering (FTCARS) microscopy. Adding a passively phase-stable local field to amplify the weak FTCARS signal, we also demonstrate interferometric FTCARS microscopy, permitting reduced incident power to be used for imaging. We discuss signal-to-noise considerations and the conditions necessary to effectively suppress background noise, allowing FTCARS microscopy that is limited by the shot noise of the detector. We also discuss differences between the signal-to-noise obtainable by time and frequency domain coherent anti-Stokes Raman scattering (CARS) methods.
© 2008 Optical Society of America
OCIS Codes
(170.6920) Medical optics and biotechnology : Time-resolved imaging
(300.6230) Spectroscopy : Spectroscopy, coherent anti-Stokes Raman scattering
(300.6310) Spectroscopy : Spectroscopy, heterodyne
ToC Category:
Microscopy
History
Original Manuscript: May 28, 2008
Revised Manuscript: September 11, 2008
Manuscript Accepted: September 26, 2008
Published: October 24, 2008
Virtual Issues
Vol. 4, Iss. 1 Virtual Journal for Biomedical Optics
Citation
Meng Cui, Joshua Skodack, and Jennifer P. Ogilvie, "Chemical imaging with Fourier transform coherent anti-Stokes Raman scattering microscopy," Appl. Opt. 47, 5790-5798 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-47-31-5790
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