Glass ampoules were always sealed by melting in the presence of a flame to create closures. Some poisonous gases were generated in this sealing process that pollute the injection drug and are physically harmful. In this study, $\mathrm{C}{\mathrm{O}}_2$ lasers were proposed for sealing glass ampoules. Because of the clean noncontact sealing process with lasers, there was nearly no pollution of the injection drug. To study in detail the principle of this sealing process, a mathematical model was put forward, and the temperature and the thermal stress field around the ampoule’s neck were calculated by ANSYS software. Through experimental study, $1\mathrm{ml}$ and $5\mathrm{ml}$ ampoules were sealed successfully by a dual-laser-beam method. The results show that a laser source is an ideal heat source for sealing glass ampoules.

© 2008 Optical Society of America

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