OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

New generation photon-counting cameras: algol and CPNG

Alain Blazit, Xavier Rondeau, Éric Thiébaut, Lyu Abe, Jean-Claude Bernengo, Jean-Louis Chevassut, Jean-Michel Clausse, Jean-Pierre Dubois, Renaud Foy, Denis Mourard, Fabien Patru, Alain Spang, Isabelle Tallon-Bosc, Michel Tallon, Yves Tourneur, and Farrokh Vakili  »View Author Affiliations


Applied Optics, Vol. 47, Issue 8, pp. 1141-1151 (2008)
http://dx.doi.org/10.1364/AO.47.001141


View Full Text Article

Enhanced HTML    Acrobat PDF (7545 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Algol and Comptage de Photons Nouvelle Génération (CPNG) are new generation photon counting cameras developed for high angular resolution in the visible by means of optical aperture synthesis and speckle interferometry and for photon noise limited fast imaging of biological targets. They are intensified CCDs. They have been built to benefit from improvements in photonic commercial components, sensitivity, and personal computer workstations processing power. We present how we achieve optimal performances (sensitivity and spatiotemporal resolution) by the combination of proper optical and electronics design, and real-time elaborated data processing. The number of pixels is 532 × 516 and 1024 2 read at a frame rate of 262 and 100 Hz for CPNG and Algol, respectively. The dark current is very low: 5.5 × 10 - 4 e . pixel 1 . s 1 . The saturation flux is 7   photon events   / pixel / s . Quantum efficiencies reach up to 36% and 26% in the visible with the GaAsP photocathodes and in the red with the GaAs ones, respectively, thanks to the sensitivity of the photocathodes and to the photon centroiding algorithm; they are likely the highest values reported for intensified CCDs.

© 2008 Optical Society of America

OCIS Codes
(030.5260) Coherence and statistical optics : Photon counting
(040.0040) Detectors : Detectors
(100.6640) Image processing : Superresolution

ToC Category:
Detectors

History
Original Manuscript: October 8, 2007
Manuscript Accepted: November 9, 2007
Published: March 10, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Alain Blazit, Xavier Rondeau, Éric Thiébaut, Lyu Abe, Jean-Claude Bernengo, Jean-Louis Chevassut, Jean-Michel Clausse, Jean-Pierre Dubois, Renaud Foy, Denis Mourard, Fabien Patru, Alain Spang, Isabelle Tallon-Bosc, Michel Tallon, Yves Tourneur, and Farrokh Vakili, "New generation photon-counting cameras: algol and CPNG," Appl. Opt. 47, 1141-1151 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-47-8-1141


Sort:  Year  |  Journal  |  Reset  

References

  1. A. Blazit, “A 40-mm photon counting camera,” Proc. SPIE 702, 259-263 (1987).
  2. R. Foy, “The photon counting camera CP40,” in Instrumentation for Ground-Based Optical Astronomy, Present and Future, Lick Observatory, eds. (Springer-Verlag, 1988), pp. 589. [CrossRef]
  3. D. Mourard, L. Abe, A. Domiciano de Souza, D. Bonneau, A. Blazit, F. Vakili, and P. Stee, “Status report on the GI2T interferometer,” Proc. SPIE 4838, 9 (2003). [CrossRef]
  4. M. Tallon, A. Baranne, A. Blazit, F.-C. Foy, R. Foy, I. Tallon-Bosc, and E. Thiébaut, “SPID, a high spectral resolution diffraction limited camera,” Proc. SPIE 4007, 962 (2000). [CrossRef]
  5. D. Mourard, D. Bonneau, J. M. Clausse, F. Hénault, A. Marcotto, A. Blazit, S. Bosio, Y. Bresson, T. ten Brummelaar, P. Kervella, S. Lagarde, H. A. McAlister, A. Mérand, G. Merlin, N. Nardetto, R. Petrov, A. Roussel, K. Rousselet-Perraut, P. Stee, J. Sturmann, L. Sturmann, and I. Tallon-Bosc, “VEGA: a visible spectrograph and polarimeter for CHARA,” Proc. SPIE 6268, 626803-1-11(2006).
  6. P. Stee, D. Mourard, D. Bonneau, P. Berlioz-Arthaud, A. Domiciano de Souza, R. Foy, P. Harmanec, S. Jankov, P. Kervella, P. Koubsky, S. Lagarde, J.-B. Le Bouquin, P. Mathias, A. Mérand, N. Nardetto, R. G. Petrov, K. Rousselet-Perraut, C. Stehle, and G. Weigelt, “VEGA: a visible spectrograph and polarimeter for CHARA--science cases description,” Proc. SPIE 6268, 62683R-1-22 (2006).
  7. R. Foy, D. Bonneau, and A. Blazit, “The multiple QSO PG1115 + 08--A fifth component?,” Astron. Astrophys. 149, L13-L16(1985).
  8. R. S. Negrin and C. H. Contag, “In vivo imaging using bioluminescence: a tool for probing graft-versus-host disease,” Nat. Rev. Immun. 6, 484-490 (2006). [CrossRef]
  9. A. Roda, P. Pasini, M. Mirasoli, E. Michelini, and M. Guardigli, “Biotechnological applications of bioluminescence and chemiluminescence,” Trends Biotechnol. 22, 295-303 (2004). [CrossRef] [PubMed]
  10. L. F. Greer, III and A. A. Szalay, “Imaging of light emission from the expression of luciferases in living cells and organisms: a review,” J. Lumin. 17, 43-74 (2002). [CrossRef]
  11. R. T. Sadikot and T. S. Blackwell, “Bioluminescence imaging,” Proc. Am. Thorac. Soc. 2, 537-540 (2005). [CrossRef] [PubMed]
  12. P. Maechler, H. Wang, and C. B. Wollheim, “Continuous monitoring of ATP levels in living insulin secreting cells expressing cytosolic firefly luciferase,” FEBS Lett. 422, 328-332(1998). [CrossRef] [PubMed]
  13. H. J. Kennedy, A. E. Pouli, E. K. Ainscow, L. S. Jouaville, R. Rizzuto, and G. A. Rutter, “Glucose generates sub-plasma membrane ATP microdomains in single islet beta-cells. Potential role for strategically located mitochondria,” J. Biol. Chem. 274, 13281-13291 (1999). [CrossRef] [PubMed]
  14. J.-L. Gach, O. Hernandez, J. Boulesteix, P. Amram, O. Boissin, C. Carignan, O. Garrido, M. Marcelin, G. Östlin, H. Plana, and R. Rampazzo, “Fabry-Pérot observations using a new GaAs photon-counting system,” in Scientific Detectors for Astronomy, The Beginning of a New Era, P. Amico, J. W. Beletic, and J. E. Beletic, eds. (Kluwer Academic, 2002), pp. 335-339.
  15. P. Jerram, P. Pool, R. Bell, D. Burt, S. Bowring, S. Spencer, M. Hazelwood, I. Moody, N. Catlett, and P. Heyes, “The LLLCCD: low light imaging without the need for an intensifier,” in Sensors and Camera Systems for Scientific, Industrial, and Digital Photography Applications II, (SPIE, 2001), pp. 178-186.
  16. M. S. Robbins and B. J. Hadwen, “The noise performance of electron multiplying charge-coupled devices,” IEEE Trans. Electron Devices 50, 1227-1232 (2003). [CrossRef]
  17. A. G. Basden, C. A. Haniff, and C. D. MacKay, “Photon counting strategies with low-light level CCDs,” Mon. Not. R. Astron. Soc. 345, 985-991 (2003). [CrossRef]
  18. O. Madelung, M. Schulz, and H. Weiss, “Intrinsic properties of group IV elements and III-V, II-VI, and I-VII compounds,” in Landolt-Bornstei, New Series, Group III (Springer, 1987).
  19. C. G. Coates, D. J. Denvir, N. G. McHale, K. D. Thornbury, and M. A. Hollywood, “Optimizing low-light microscopy with back-illuminated electron multiplying charge-coupled device: enhanced sensitivity, speed, and resolution,” J. Biomed. Opt. 9, 1244-1252 (2004). [CrossRef] [PubMed]
  20. J.-L. Gach, C. Guillaume, O. Boissin, and C. Cavadore, “First results of an L3CCD in photon counting mode,” in Astrophysics and Space Science Library (2004), pp. 611-614. [CrossRef]
  21. E. Thiébaut, “Speckle interferometry with a photon-counting detector,” Astron. Astrophys. 284, 340-348 (1994).
  22. E. Thiébaut, “Avoiding the photon-counting hole in speckle imaging by means of cross-correlation techniques,” J. Opt. Soc. Am. A 14, 122-130 (1997). [CrossRef]
  23. R. Michel, J. Fordham, and H. Kawakami, “Fixed pattern noise in high-resolution, CCD readout photon-counting detectors,” Mon. Not. R. Astron. Soc. 292, 611-620 (1997).
  24. J. J. Moré and D. C. Sorensen, “Computing a trust region step,” SIAM (Soc. Ind. Appl. Math.) J. Sci. Stat. Comput. 4, 553-572 (1983).
  25. M. K. Carter, R. Cutler, B. E. Patchett, P. D. Read, N. R. Waltham, and I. G. van Breda, “Transputer-based image photon-counting detector,” in Instrumentation in Astronomy VII, Proc. SPIE 1235, 644-656 (1990).

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited