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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 6 — May. 26, 2009

State-dependent auditory evoked hemodynamic responses recorded optically with indwelling photodiodes

Jennifer L. Schei, Amanda J. Foust, Manuel J. Rojas, Jinna A. Navas, and David M. Rector  »View Author Affiliations

Applied Optics, Vol. 48, Issue 10, pp. D121-D129 (2009)

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Implantable optical technologies provide measurements of cerebral hemodynamic activity from freely behaving animals without movement constraint or anesthesia. In order to study state-dependent neural evoked responses and the consequential hemodynamic response, we simultaneously measured EEG and scattered light changes in chronically implanted rats. Recordings took place under freely behaving conditions, allowing us to compare the evoked responses across wake, sleep, and anesthetized states. The largest evoked electrical and optical responses occurred during quiet sleep compared to wake and REM sleep, while isoflurane anesthesia showed a large, late burst of electrical activity synchronized to the stimulus but an earlier optical response.

© 2009 Optical Society of America

OCIS Codes
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.2655) Medical optics and biotechnology : Functional monitoring and imaging

Original Manuscript: September 3, 2008
Revised Manuscript: December 19, 2008
Manuscript Accepted: January 8, 2009
Published: February 13, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Jennifer L. Schei, Amanda J. Foust, Manuel J. Rojas, Jinna A. Navas, and David M. Rector, "State-dependent auditory evoked hemodynamic responses recorded optically with indwelling photodiodes," Appl. Opt. 48, D121-D129 (2009)

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