Multiplexed low coherence interferometry instrument for measuring microbicide gel thickness distribution
Applied Optics, Vol. 48, Issue 10, pp. D14-D19 (2009)
http://dx.doi.org/10.1364/AO.48.000D14
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Abstract
We present a Fourier-domain, multiplexed low coherence interferometry (LCI) instrument designed for application to intravaginal measurement of microbicidal gel distribution. Microbicide gels are topical products developed to combat sexually transmitted diseases, such as HIV/AIDS, by acting as delivery vehicles for active drugs and barrier layers to vaginal tissue. Measuring microbicide gel vaginal distribution is key to understanding the gel’s biological effectiveness. This study presents a new LCI system for measuring gel distribution that uses six multiplexed channels to achieve broad area scanning without the need for a mechanical scanner. The presented results characterize the performance of the Fourier-domain multiplexed LCI system in measuring gel thickness distribution. The system demonstrates good optical signal-to-noise ratio, steady performance across all channels, negligible cross talk, and accurate measurement with micrometer scale resolution. The potential impact of using a multiplexed LCI system for in vivo measurements is also discussed.
© 2008 Optical Society of America
OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(170.4500) Medical optics and biotechnology : Optical coherence tomography
History
Original Manuscript: June 16, 2008
Revised Manuscript: October 21, 2008
Manuscript Accepted: October 24, 2008
Published: December 3, 2008
Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics
Citation
Tyler K. Drake, Francisco E. Robles, and Adam Wax, "Multiplexed low coherence interferometry instrument for measuring microbicide gel thickness distribution," Appl. Opt. 48, D14-D19 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-48-10-D14
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