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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 6 — May. 26, 2009

Near-infrared spectral imaging of the female breast for quantitative oximetry in optical mammography

Yang Yu, Ning Liu, Angelo Sassaroli, and Sergio Fantini  »View Author Affiliations

Applied Optics, Vol. 48, Issue 10, pp. D225-D235 (2009)

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We present a hybrid continuous-wave, frequency-domain instrument for near-infrared spectral imaging of the female breast based on a tandem, planar scanning of one illumination optical fiber and one collection optical fiber configured in a transmission geometry. The spatial sampling rate of 25   points / cm 2 is increased to 400 points / cm 2 by postprocessing the data with a 2D cubic spline interpolation. We then apply a previously developed spatial second-derivative algorithm to an edge-corrected intensity image (N-image) to enhance the visibility and resolution of optical inhomogeneities in breast tissue such as blood vessels and tumors. The spectral data at each image pixel consist of 515-point spectra over the 650 900 nm wavelength range, thus featuring a spectral density of two data points per nanometer. We process the measured spectra with a paired-wavelength spectral analysis method to quantify the oxygen saturation of detected optical inhomogeneities, under the assumption that they feature a locally higher hemoglobin concentration. Our initial measurements on two healthy human subjects have generated high-resolution optical mammograms displaying a network of blood vessels with values of hemoglobin saturation typically falling within the 60%–95% range, which is physiologically reasonable. This approach to spectral imaging and oximetry of the breast has the potential to efficiently exploit the high intrinsic contrast provided by hemoglobin in breast tissue and to contribute a useful tool in the detection, diagnosis, and monitoring of breast pathologies.

© 2009 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3830) Medical optics and biotechnology : Mammography
(170.5280) Medical optics and biotechnology : Photon migration

Original Manuscript: September 12, 2008
Revised Manuscript: January 9, 2009
Manuscript Accepted: January 18, 2009
Published: March 2, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Yang Yu, Ning Liu, Angelo Sassaroli, and Sergio Fantini, "Near-infrared spectral imaging of the female breast for quantitative oximetry in optical mammography," Appl. Opt. 48, D225-D235 (2009)

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