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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 6 — May. 26, 2009

Optical characterization of the nanoscale organization of mineral deposits on silk films

Sharad Gupta, Martin Hunter, David Kaplan, and Irene Georgakoudi  »View Author Affiliations


Applied Optics, Vol. 48, Issue 10, pp. D45-D51 (2009)
http://dx.doi.org/10.1364/AO.48.000D45


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Abstract

The alignment of deposited minerals in tissues such as bone and teeth plays a critical role in the mechanical properties of these tissues. Therefore, assessment of features that are characteristic of aligned biominerals could aid in the development of novel biomaterials and engineered tissues that can be used to replace damaged or defective human tissues. In this study, we demonstrate that light scattering spectroscopy can serve as a useful tool for the noninvasive characterization of mineralization on aligned organic substrates. Specifically, we used silk films with oriented and nonoriented secondary structures as a protein matrix for control of mineralization. The mineral deposits displayed self-affine fractal morphologies with the oriented films yielding a significantly higher Hurst parameter, which in turn suggests higher levels of fractal organization. In addition, the value of the upper bound of fractal correlation lengths was significantly smaller for the oriented than for the nonoriented films and correlated well with the size of the corresponding nanocrystalline mineral beads identified by scanning electron microscope imaging.

© 2009 Optical Society of America

OCIS Codes
(290.1350) Scattering : Backscattering
(160.1435) Materials : Biomaterials
(290.5855) Scattering : Scattering, polarization

History
Original Manuscript: September 2, 2008
Manuscript Accepted: October 31, 2008
Published: January 9, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Sharad Gupta, Martin Hunter, David Kaplan, and Irene Georgakoudi, "Optical characterization of the nanoscale organization of mineral deposits on silk films," Appl. Opt. 48, D45-D51 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-48-10-D45

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