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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 7 — Jul. 1, 2009

Whole blood reflectance for assessment of hematologic condition and detection of angiographic contrast media

Hyeonsoo Chang, Young L. Kim, Ali Hassan, and Peter J. Fitzgerald  »View Author Affiliations

Applied Optics, Vol. 48, Issue 13, pp. 2435-2443 (2009)

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We present simple whole blood reflectance analyses in the range 500– 900 nm , using intact whole blood to simultaneously quantify hematocrit and oxygen saturation from a single spectral reading. We applied these results for the development of an intravascular catheter-based reflectance sensing system to detect and remove contrast media injected during angiography so as to reduce the risk of complications associated with the injected contrast media. We further tested the practicality of the optical detection of angiographic contrast media in a pilot animal study in vivo. We successfully demonstrated the feasibility of real-time in vivo contrast detection and removal during angiography. Our simple method for the detection and removal of angiographic contrast media will facilitate the development of intravascular optical sensing systems.

© 2009 Optical Society of America

OCIS Codes
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.1470) Medical optics and biotechnology : Blood or tissue constituent monitoring
(170.1610) Medical optics and biotechnology : Clinical applications
(170.3890) Medical optics and biotechnology : Medical optics instrumentation

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: December 1, 2008
Revised Manuscript: March 16, 2009
Manuscript Accepted: March 28, 2009
Published: April 22, 2009

Virtual Issues
Vol. 4, Iss. 7 Virtual Journal for Biomedical Optics

Hyeonsoo Chang, Young L. Kim, Ali Hassan, and Peter J. Fitzgerald, "Whole blood reflectance for assessment of hematologic condition and detection of angiographic contrast media," Appl. Opt. 48, 2435-2443 (2009)

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