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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 10 — Oct. 2, 2009

Nonlinear reconstruction of absorption and fluorescence contrast from measured diffuse transmittance and reflectance of a compressed-breast-simulating phantom

Ronny Ziegler, Tim Nielsen, Thomas Koehler, Dirk Grosenick, Oliver Steinkellner, Axel Hagen, Rainer Macdonald, and Herbert Rinneberg  »View Author Affiliations


Applied Optics, Vol. 48, Issue 24, pp. 4651-4662 (2009)
http://dx.doi.org/10.1364/AO.48.004651


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Abstract

We report on the nonlinear reconstruction of local absorption and fluorescence contrast in tissuelike scattering media from measured time-domain diffuse reflectance and transmittance of laser as well as laser-excited fluorescence radiation. Measurements were taken at selected source–detector offsets using slablike diffusely scattering and fluorescent phantoms containing fluorescent heterogeneities. Such measurements simulate in vivo data that would be obtained employing a scanning, time-domain fluorescence mammograph, where the breast is gently compressed between two parallel glass plates, and source and detector optical fibers scan synchronously at various source–detector offsets, allowing the recording of laser and fluorescence mammograms. The diffusion equations modeling the propagation of the laser and fluorescence radiation were solved in frequency domain by the finite element method simultaneously for several modulation frequencies using Fourier transformation and preprocessed experimental data. To reconstruct the concentration of the fluorescent contrast agent, the Born approximation including higher-order reconstructed photon densities at the excitation wavelength was used. Axial resolution was determined that can be achieved by various detection schemes. We show that remission measurements increase the depth resolution significantly.

© 2009 Optical Society of America

OCIS Codes
(100.3010) Image processing : Image reconstruction techniques
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3830) Medical optics and biotechnology : Mammography
(170.7050) Medical optics and biotechnology : Turbid media

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: October 21, 2008
Revised Manuscript: July 19, 2009
Manuscript Accepted: July 21, 2009
Published: August 11, 2009

Virtual Issues
Vol. 4, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Ronny Ziegler, Tim Nielsen, Thomas Koehler, Dirk Grosenick, Oliver Steinkellner, Axel Hagen, Rainer Macdonald, and Herbert Rinneberg, "Nonlinear reconstruction of absorption and fluorescence contrast from measured diffuse transmittance and reflectance of a compressed-breast-simulating phantom," Appl. Opt. 48, 4651-4662 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-48-24-4651


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