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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 11 — Oct. 21, 2009

Microvalve thickness and topography measurements in microfluidic devices by white-light confocal microscopy

Shiguang Li, Todd Thorsen, Zhiguang Xu, Zhong Ping Fang, Jianhong Zhao, and Soon Fatt Yoon  »View Author Affiliations


Applied Optics, Vol. 48, Issue 27, pp. 5088-5094 (2009)
http://dx.doi.org/10.1364/AO.48.005088


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Abstract

A microvalve is a key part in a multilayer microfluidic device to control the fluid flow, and its thickness directly determines its performance. In this paper, a three-dimensional measurement technology using a white-light confocal microscope is developed for measuring both the topography and thickness of microvalves. The impact of system parameters and sample parameters on measurement accuracy is discussed in detail, particularly for measurement with a dry objective. With this technique, the microvalve thicknesses before and after bonding were characterized with submicrometer measurement sensitivity and about 1 μm measurement accuracy.

© 2009 Optical Society of America

OCIS Codes
(080.0080) Geometric optics : Geometric optics
(080.1010) Geometric optics : Aberrations (global)
(110.2960) Imaging systems : Image analysis
(110.6880) Imaging systems : Three-dimensional image acquisition
(180.1790) Microscopy : Confocal microscopy

ToC Category:
Microscopy

History
Original Manuscript: June 9, 2009
Revised Manuscript: August 8, 2009
Manuscript Accepted: August 9, 2009
Published: September 10, 2009

Virtual Issues
Vol. 4, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Shiguang Li, Todd Thorsen, Zhiguang Xu, Zhong Ping Fang, Jianhong Zhao, and Soon Fatt Yoon, "Microvalve thickness and topography measurements in microfluidic devices by white-light confocal microscopy," Appl. Opt. 48, 5088-5094 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-48-27-5088

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