Enhancement of guided-wave two-photon-excited luminescence response with a photonic-crystal fiber
Applied Optics, Vol. 48, Issue 28, pp. 5274-5279 (2009)
http://dx.doi.org/10.1364/AO.48.005274
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Abstract
Photonic-crystal fiber (PCF) is shown to substantially increase the guided-wave luminescent response from molecules excited through two-photon absorption (TPA) by femtosecond near-infrared laser pulses. With only a few nanoliters of TPA-excited molecules filling airholes in a specifically designed PCF, the guided-wave two-photon-excited luminescence (TPL) signal is enhanced by more than 2 orders of magnitude relative to the maximum TPL signal attainable from a cell with the same dye excited and collected by the same PCF. Biophotonic implications of this waveguide TPL-response enhancement include fiber-format solutions for online monitoring of drug delivery and drug activation, interrogation of neural activity, biosensing, endoscopy, and locally controlled singlet oxygen generation in photodynamic therapy.
© 2009 Optical Society of America
OCIS Codes
(190.4370) Nonlinear optics : Nonlinear optics, fibers
(060.4005) Fiber optics and optical communications : Microstructured fibers
ToC Category:
Fiber Optics and Optical Communications
History
Original Manuscript: May 26, 2009
Revised Manuscript: July 30, 2009
Manuscript Accepted: August 19, 2009
Published: September 21, 2009
Virtual Issues
Vol. 4, Iss. 12 Virtual Journal for Biomedical Optics
Citation
Ilya V. Fedotov, Andrei B. Fedotov, Lyubov V. Doronina, and Aleksei M. Zheltikov, "Enhancement of guided-wave two-photon-excited luminescence response with a photonic-crystal fiber," Appl. Opt. 48, 5274-5279 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-48-28-5274
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