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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 13 — Dec. 2, 2009

Improved differential confocal microscopy with ultrahigh signal-to-noise ratio and reflectance disturbance resistibility

Jian Liu, Jiubin Tan, Hu Bin, and Yuhang Wang  »View Author Affiliations


Applied Optics, Vol. 48, Issue 32, pp. 6195-6201 (2009)
http://dx.doi.org/10.1364/AO.48.006195


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Abstract

Improved differential confocal microscopy is proposed to improve axial resolution and to enhance disturbance resistibility of confocal microscopy. The subtraction and sum values of the two defocusing detected signals are divided as the response function. Both ultrahigh signal-to-noise ratio (SNR) and wide range can be selectively obtained by controlling the defocusing amount of the two differential detectors more tightly with the reflectance disturbance resistibility. Since the detecting sensitivity of the proposed confocal microscopy is unrelated to the energy loss of the reflected beam, the multiplicative mode disturbance can be used to measure microstructures made of hybrid materials and overcome the power drift of a laser source during long scanning. In the case of ultrahigh SNR, the axial resolution reaches 1 nm when NA = 0.75 and λ = 632.8 nm .

© 2009 Optical Society of America

OCIS Codes
(180.1790) Microscopy : Confocal microscopy
(180.3170) Microscopy : Interference microscopy
(180.5810) Microscopy : Scanning microscopy

ToC Category:
Microscopy

History
Original Manuscript: June 3, 2009
Revised Manuscript: October 2, 2009
Manuscript Accepted: October 16, 2009
Published: November 3, 2009

Virtual Issues
Vol. 4, Iss. 13 Virtual Journal for Biomedical Optics

Citation
Jian Liu, Jiubin Tan, Hu Bin, and Yuhang Wang, "Improved differential confocal microscopy with ultrahigh signal-to-noise ratio and reflectance disturbance resistibility," Appl. Opt. 48, 6195-6201 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-48-32-6195

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