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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 4 — Apr. 1, 2009

Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements

Krishnan R. Parameswaran, David I. Rosen, Mark G. Allen, Alan M. Ganz, and Terence H. Risby  »View Author Affiliations


Applied Optics, Vol. 48, Issue 4, pp. B73-B79 (2009)
http://dx.doi.org/10.1364/AO.48.000B73


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Abstract

Cavity-enhanced tunable diode laser absorption spectroscopy is an attractive method for measuring small concentrations of gaseous species. Ethane is a breath biomarker of lipid peroxidation initiated by reactive oxygen species. A noninvasive means of quickly quantifying oxidative stress status has the potential for broad clinical application. We present a simple, compact system using off-axis integrated cavity output spectroscopy with an interband cascade laser and demonstrate its use in real-time measurements of breath ethane. We demonstrate a detection sensitivity of 0.48 ‚ÄČ ppb / Hz 1 / 2 .

© 2008 Optical Society of America

OCIS Codes
(280.0280) Remote sensing and sensors : Remote sensing and sensors
(300.0300) Spectroscopy : Spectroscopy

History
Original Manuscript: July 17, 2008
Revised Manuscript: October 24, 2008
Manuscript Accepted: November 1, 2008
Published: December 8, 2008

Virtual Issues
Vol. 4, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Krishnan R. Parameswaran, David I. Rosen, Mark G. Allen, Alan M. Ganz, and Terence H. Risby, "Off-axis integrated cavity output spectroscopy with a mid-infrared interband cascade laser for real-time breath ethane measurements," Appl. Opt. 48, B73-B79 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-48-4-B73

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