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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 5 — May. 5, 2009

Quantitative fluorescence tomography with functional and structural a priori information

Yuting Lin, Han Yan, Orhan Nalcioglu, and Gultekin Gulsen  »View Author Affiliations


Applied Optics, Vol. 48, Issue 7, pp. 1328-1336 (2009)
http://dx.doi.org/10.1364/AO.48.001328


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Abstract

We demonstrate the necessity of functional and structural a priori information for quantitative fluorescence tomography (FT) with phantom studies. Here the functional a priori information is defined as the optical properties of the heterogeneous background that can be measured by a diffuse optical tomography (DOT) system. A CCD-based noncontact hybrid FT/DOT system that could take measurements at multiple views was built. Multimodality phantoms with multiple compartments were constructed and used in the experiments to mimic a heterogeneous optical background. A 3.6 mm diameter object deeply embedded in a heterogeneous optical background could be localized without any a priori information, but the recovered fluorophore concentration only reached one tenth of the true concentration. On the other hand, the true fluorophore concentration could be recovered when both functional and structural a priori information is utilized to guide and constrain the FT reconstruction algorithm.

© 2009 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.6960) Medical optics and biotechnology : Tomography

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: August 13, 2008
Revised Manuscript: November 11, 2008
Manuscript Accepted: January 17, 2009
Published: February 23, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Yuting Lin, Han Yan, Orhan Nalcioglu, and Gultekin Gulsen, "Quantitative fluorescence tomography with functional and structural a priori information," Appl. Opt. 48, 1328-1336 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-48-7-1328


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