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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 8 — Jun. 8, 2010

Spatially deconvolved optical coherence tomography

Peter D. Woolliams, Robert A. Ferguson, Christian Hart, Alex Grimwood, and Peter H. Tomlins  »View Author Affiliations


Applied Optics, Vol. 49, Issue 11, pp. 2014-2021 (2010)
http://dx.doi.org/10.1364/AO.49.002014


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Abstract

In this paper we present spatially mapped point-spread function (PSF) measurements of an optical coherence tomography (OCT) instrument and subsequent spatial deconvolution. The OCT B-scan image plane was divided into 2400 subimages, for which PSFs were determined from OCT measurements of a specially designed phantom. Each PSF was deconvolved from its corresponding subimage of the phantom using the Lucy–Richardson algorithm. Following deconvolution, all of the subimages were reassembled to form a final deconvolved image, from which the resolution improvement was quantitatively assessed. The lateral resolution was found to improve by 3.1 μm compared to an axial resolution enhancement of 4.5 μm . The spatial uniformity of both axial and lateral resolution was also observed to increase following deconvolution, demonstrating the advantage of deconvolving local PSFs from their associated subimages.

© 2010 Optical Society of America

OCIS Codes
(100.1830) Image processing : Deconvolution
(110.4500) Imaging systems : Optical coherence tomography
(330.6130) Vision, color, and visual optics : Spatial resolution
(350.4800) Other areas of optics : Optical standards and testing
(350.5730) Other areas of optics : Resolution

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: November 18, 2009
Revised Manuscript: March 2, 2010
Manuscript Accepted: March 11, 2010
Published: April 1, 2010

Virtual Issues
Vol. 5, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Peter D. Woolliams, Robert A. Ferguson, Christian Hart, Alex Grimwood, and Peter H. Tomlins, "Spatially deconvolved optical coherence tomography," Appl. Opt. 49, 2014-2021 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-49-11-2014

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