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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 11 — Aug. 25, 2010

Quantitative photoacoustic tomography with multiple optical sources

Roger J. Zemp  »View Author Affiliations

Applied Optics, Vol. 49, Issue 18, pp. 3566-3572 (2010)

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Quantitative imaging of optical properties of biological tissues with high resolution has been a long-sought-after goal of many research groups. Photoacoustic imaging is a hybrid bio-optical imaging technique offering optical absorption contrast with ultrasonic spatial resolution. While photoacoustic methods offer significant promise for high-resolution optical imaging, quantification has thus far proved challenging. In this paper, a noniterative reconstruction technique for producing quantitative photoacoustic images of absorption perturbations is introduced for the case when the optical properties of the turbid background are known and when multiple optical illumination locations are used. Through theoretical developments and computational examples it is demonstrated that multiple-optical-source photoacoustic imaging can produce quantitative optical absorption reconstructions. The combination of optical and photoacoustic measurements is shown to yield improved reconstruction stability.

© 2010 Optical Society of America

OCIS Codes
(110.2990) Imaging systems : Image formation theory
(110.5120) Imaging systems : Photoacoustic imaging
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(110.0113) Imaging systems : Imaging through turbid media
(110.3010) Imaging systems : Image reconstruction techniques

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: November 30, 2009
Revised Manuscript: May 18, 2010
Manuscript Accepted: May 25, 2010
Published: June 17, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Roger J. Zemp, "Quantitative photoacoustic tomography with multiple optical sources," Appl. Opt. 49, 3566-3572 (2010)

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