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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 11 — Aug. 25, 2010

Limitations imposed by specimen phase gradients on the design of grating based x-ray phase contrast imaging systems

Peter R. T. Munro, Konstantin Ignatyev, Robert D. Speller, and Alessandro Olivo  »View Author Affiliations


Applied Optics, Vol. 49, Issue 20, pp. 3860-3863 (2010)
http://dx.doi.org/10.1364/AO.49.003860


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Abstract

X-ray phase contrast imaging is a very promising technique that may lead to significant advancements in a variety of fields, perhaps most notably, medical imaging. The radiation physics group at University College London is currently developing an x-ray phase contrast imaging technique that works with laboratory x-ray sources. This system essentially measures the degree to which photons are refracted by regions of an imaged object. The amount of refraction that may be expected to be encountered in practice impacts strongly upon the design of the imaging system. In this paper, we derive an approximate expression between the properties of archetypal imaged objects encountered in practice and the resulting distribution of refracted photons. This is used to derive constraints governing the design of the system.

© 2010 Optical Society of America

OCIS Codes
(050.1960) Diffraction and gratings : Diffraction theory
(110.7440) Imaging systems : X-ray imaging
(340.7430) X-ray optics : X-ray coded apertures

ToC Category:
Diffraction and Gratings

History
Original Manuscript: April 8, 2010
Revised Manuscript: June 14, 2010
Manuscript Accepted: June 15, 2010
Published: July 2, 2010

Virtual Issues
Vol. 5, Iss. 11 Virtual Journal for Biomedical Optics

Citation
Peter R. T. Munro, Konstantin Ignatyev, Robert D. Speller, and Alessandro Olivo, "Limitations imposed by specimen phase gradients on the design of grating based x-ray phase contrast imaging systems," Appl. Opt. 49, 3860-3863 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-49-20-3860


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References

  1. A. Momose, W. Yashiro, Y. Takeda, Y. Suzuki, and T. Hattori, “Phase tomography by x-ray Talbot interferometry for biological imaging,” Jpn. J. Appl. Phys. 45, 5254–5262 (2006). [CrossRef]
  2. F. Pfeiffer, T. Weitkamp, O. Bunk, and C. David, “Phase retrieval and differential phase-contrast imaging with low-brilliance x-ray sources,” Nature Phys. 2, 258–261 (2006). [CrossRef]
  3. A. Olivo and R. Speller, “A coded-aperture technique allowing x-ray phase contrast imaging with conventional sources,” Appl. Phys. Lett. 91, 074106 (2007). [CrossRef]
  4. M. Born and E. Wolf, Principles of Optics, 7th ed. (Cambridge U. Press, 1999).
  5. P. Munro, K. Ignatyev, R. Speller, and A. Olivo, “The relationship between wave and geometrical optics models of coded aperture type x-ray phase contrast imaging systems,” Opt. Express 18, 4103–4117 (2010). [CrossRef] [PubMed]
  6. A. Momose, S. Kawamoto, I. Koyama, Y. Hamaishi, K. Takai, and Y. Suzuki, “Demonstration of x-ray Talbot interferometry,” Jpn. J. Appl. Phys. 42, L866–L868 (2003). [CrossRef]

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