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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 5, Iss. 7 — Apr. 26, 2010

Quantitative determination of chromophore concentrations from 2D photoacoustic images using a nonlinear model-based inversion scheme

Jan Laufer, Ben Cox, Edward Zhang, and Paul Beard  »View Author Affiliations


Applied Optics, Vol. 49, Issue 8, pp. 1219-1233 (2010)
http://dx.doi.org/10.1364/AO.49.001219


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Abstract

A model-based inversion scheme was used to determine absolute chromophore concentrations from multiwavelength photoacoustic images. The inversion scheme incorporated a forward model, which predicted 2D images of the initial pressure distribution as a function of the spatial distribution of the chromophore concentrations. It comprised a multiwavelength diffusion based model of the light transport, a model of acoustic propagation and detection, and an image reconstruction algorithm. The model was inverted by fitting its output to measured photoacoustic images to determine the chromophore concentrations. The scheme was validated using images acquired in a tissue phantom at wavelengths between 590 nm and 980 nm . The phantom comprised a scattering emulsion in which up to four tubes, filled with absorbing solutions of copper and nickel chloride at different concentration ratios, were submerged. Photoacoustic signals were detected along a line perpendicular to the tubes from which images of the initial pressure distribution were reconstructed. By varying the excitation wavelength, sets of multiwavelength photoacoustic images were obtained. The majority of the determined chromophore concentrations were within ± 15 % of the true value, while the concentration ratios were determined with an average accuracy of 1.2 % .

© 2010 Optical Society of America

OCIS Codes
(100.3190) Image processing : Inverse problems
(170.5120) Medical optics and biotechnology : Photoacoustic imaging
(300.0300) Spectroscopy : Spectroscopy

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 30, 2009
Revised Manuscript: December 11, 2009
Manuscript Accepted: December 19, 2009
Published: March 3, 2010

Virtual Issues
Vol. 5, Iss. 7 Virtual Journal for Biomedical Optics

Citation
Jan Laufer, Ben Cox, Edward Zhang, and Paul Beard, "Quantitative determination of chromophore concentrations from 2D photoacoustic images using a nonlinear model-based inversion scheme," Appl. Opt. 49, 1219-1233 (2010)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-49-8-1219

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