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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 8 — Aug. 26, 2011

Dual-order snapshot spectral imaging of plasmonic nanoparticles

Gregory J. Nusz, Stella M. Marinakos, Srinath Rangarajan, and Ashutosh Chilkoti  »View Author Affiliations


Applied Optics, Vol. 50, Issue 21, pp. 4198-4206 (2011)
http://dx.doi.org/10.1364/AO.50.004198


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Abstract

The development of truly scalable, multiplexed optical microarrays requires a detection platform capable of simultaneous detection of multiple signals in real-time. We present a technique we term dual-order snapshot spectroscopic imaging (DOSSI) and demonstrate that it can be effectively used to collect spectrally resolved images of a full field of view of sparsely located spots in real time. Resonant peaks of plasmonic gold nanoparticles were tracked as a function of their surrounding refractive index. Measurement uncertainty analysis indicated that the spectral resolution of DOSSI in the described configuration is approximately 0.95 nm . Further, real-time measurements by DOSSI allowed discrimination between optically identical nanoparticles that were functionalized with two homologous small molecule ligands that bound to the same protein, albeit with different affinity, based purely on their different molecular interaction kinetics—a feat not possible with slower raster-type hyperspectral imaging systems, or other dark-field optical detection systems that solely rely on end point measurements. Kinetic measurements of plasmon bands by DOSSI can be performed with a relatively simple optical system, thereby opening up the possibility of developing low-cost detectors for arrayed plasmonic diagnostics.

© 2011 Optical Society of America

OCIS Codes
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(110.4234) Imaging systems : Multispectral and hyperspectral imaging

ToC Category:
Imaging Systems

History
Original Manuscript: February 23, 2011
Revised Manuscript: June 6, 2011
Manuscript Accepted: June 9, 2011
Published: July 19, 2011

Virtual Issues
Vol. 6, Iss. 8 Virtual Journal for Biomedical Optics

Citation
Gregory J. Nusz, Stella M. Marinakos, Srinath Rangarajan, and Ashutosh Chilkoti, "Dual-order snapshot spectral imaging of plasmonic nanoparticles," Appl. Opt. 50, 4198-4206 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-50-21-4198


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References

  1. J. N. Anker, W. P. Hall, O. Lyandres, N. C. Shah, J. Zhao, and R. P. Van Duyne, “Biosensing with plasmonic nanosensors,” Nat. Mater. 7, 442–453 (2008). [CrossRef] [PubMed]
  2. T. Endo, H. Takizawa, Y. Yanagida, T. Hatsuzawa, and E. Tamiya, “Construction of a biosensor operating on the combined principles of electrochemical analysis and localized surface plasmon resonance for multiple detection of antigen–antibody and enzymatic reactions on the single biosensor,” Sens. Mater. 20, 255–265 (2008).
  3. N. Nath and A. Chilkoti, “A colorimetric gold nanoparticle sensor to interrogate biomolecular interactions in real time on a surface,” Anal. Chem. 74, 504–509 (2002). [CrossRef] [PubMed]
  4. G. J. Nusz, S. M. Marinakos, A. C. Curry, A. Dahlin, F. Höök, A. Wax, and A. Chilkoti, “Label-free plasmonic detection of biomolecular binding by a single gold nanorod,” Anal. Chem. 80, 984–989 (2008). [CrossRef] [PubMed]
  5. A. D. McFarland and R. P. Van Duyne, “Single silver nanoparticles as real-time optical sensors with zeptomole sensitivity,” Nano Lett. 3, 1057–1062 (2003). [CrossRef]
  6. G. Raschke, S. Brogl, A. S. Susha, A. L. Rogach, T. A. Klar, J. Feldmann, B. Fieres, N. Petkov, T. Bein, A. Nichtl, and K. Kurzinger, “Gold nanoshells improve single nanoparticle molecular sensors,” Nano Lett. 4, 1853–1857 (2004). [CrossRef]
  7. T. Rindzevicius, Y. Alaverdyan, A. Dahlin, F. Höök, D. S. Sutherland, and M. Käll, “Plasmonic sensing characteristics of single nanometric holes,” Nano Lett. 5, 2335–2339 (2005). [CrossRef] [PubMed]
  8. C. X. Yu and J. Irudayaraj, “Multiplex biosensor using gold nanorods,” Anal. Chem. 79, 572–579 (2007). [CrossRef] [PubMed]
  9. J. Homola, “Surface plasmon resonance sensors for detection of chemical and biological species,” Chem. Rev. 108, 462–493(2008). [CrossRef] [PubMed]
  10. M. E. Gehm, R. John, D. J. Brady, R. M. Willett, and T. J. Schulz, “Single-shot compressive spectral imaging with a dual-disperser architecture,” Opt. Express 15, 14013–14027(2007). [CrossRef] [PubMed]
  11. C. F. Cull, K. Choi, D. J. Brady, and T. Oliver, “Identification of fluorescent beads using a coded aperture snapshot spectral imager,” Appl. Opt. 49, B59–B70. [CrossRef] [PubMed]
  12. J. Cheng, Y. Liu, X. D. Cheng, Y. He, and E. S. Yeung, “Real time observation of chemical reactions of individual metal nanoparticles with high-throughput single molecule spectral microscopy,” Anal. Chem. 82, 8744–8749 (2010). [CrossRef] [PubMed]
  13. Y. F. Ma, M. R. Shortreed, and E. S. Yeung, “High-throughput single-molecule spectroscopy in free solution,” Anal. Chem. 72, 4640–4645 (2000). [CrossRef] [PubMed]
  14. A. Curry, G. Nusz, A. Chilkoti, and A. Wax, “Analysis of total uncertainty in spectral peak measurements for plasmonic nanoparticle-based biosensors,” Appl. Opt. 46, 1931–1939(2007). [CrossRef] [PubMed]
  15. B. Nikoobakht and M. A. El-Sayed, “Preparation and growth mechanism of gold nanorods (nrs) using seed-mediated growth method,” Chem. Mater. 15, 1957–1962 (2003). [CrossRef]
  16. N. R. Jana, L. Gearheart, and C. J. Murphy, “Seed-mediated growth approach for shape-controlled synthesis of spheroidal and rod-like gold nanoparticles using a surfactant template,” Adv. Mater. 13, 1389–1393 (2001). [CrossRef]
  17. R. Sardar, T. B. Heap, and J. S. Shumaker-Parry, “Versatile solid phase synthesis of gold nanoparticle dimers using an asymmetric functionalization approach,” J. Am. Chem. Soc. 129, 5356–5357 (2007). [CrossRef] [PubMed]
  18. N. M. Green, “Thermodynamics of binding of biotin and some analogues by avidin,” Biochem. J. 101, 774–780 (1966). [PubMed]
  19. M. Guizar-Sicairos, S. T. Thurman, and J. R. Fienup, “Efficient subpixel image registration algorithms,” Opt. Lett. 33, 156–158 (2008). [CrossRef] [PubMed]
  20. T. O’Haver, “Peak finding and measurement,” http://www.mathworks.com/matlabcentral/fileexchange/11755 (2009).
  21. M. M. Miller and A. A. Lazarides, “Sensitivity of metal nanoparticle surface plasmon resonance to the dielectric environment,” J. Phys. Chem. B 109, 21556–21565 (2005). [CrossRef]
  22. M. M. Miller and A. A. Lazarides, “Sensitivity of metal nanoparticle plasmon resonance band position to the dielectric environment as observed in scattering,” J. Opt. A 8, S239–S249 (2006). [CrossRef]
  23. A. Chilkoti, P. H. Tan, and P. S. Stayton, “Site-directed mutagenesis studies of the high-affinity streptavidin–biotin complex—contributions of tryptophan residue-79, residue-108, and residue-120,” Proc. Natl Acad. Sci USA 92,1754–1758 (1995). [CrossRef] [PubMed]
  24. M. Wilchek and E. A. Bayer, “The avidin biotin complex in bioanalytical applications,” Anal. Biochem. 171, 1–32 (1988). [CrossRef] [PubMed]
  25. G. J. Nusz, A. C. Curry, S. M. Marinakos, A. Wax, and A. Chilkoti, “Rational selection of gold nanorod geometry for label-free plasmonic biosensors,” ACS Nano 3, 795–806(2009). [CrossRef] [PubMed]

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