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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 3 — Mar. 18, 2011

Axial-scanning low-coherence interferometer method for noncontact thickness measurement of biological samples

Do-Hyun Kim, Chul-Gyu Song, Ilko K. Ilev, and Jin U. Kang  »View Author Affiliations


Applied Optics, Vol. 50, Issue 6, pp. 970-974 (2011)
http://dx.doi.org/10.1364/AO.50.000970


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Abstract

We investigated a high-precision optical method for measuring the thickness of biological samples regardless of their transparency. The method is based on the precise measurement of optical path length difference of the end surfaces of objects, using a dual-arm axial-scanning low-coherence interferometer. This removes any consideration of the shape, thickness, or transparency of testing objects when performing the measurement. Scanning the reference simplifies the measurement setup, resulting in unambiguous measurement. Using a 1310 nm wavelength superluminescent diode, with a 65 nm bandwidth, the measurement accuracy was as high as 11.6 μm . We tested the method by measuring the thickness of both transparent samples and nontransparent soft biological tissues.

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(120.0120) Instrumentation, measurement, and metrology : Instrumentation, measurement, and metrology
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Instrumentation, Measurement, and Metrology

History
Original Manuscript: December 8, 2010
Manuscript Accepted: December 28, 2010
Published: February 17, 2011

Virtual Issues
Vol. 6, Iss. 3 Virtual Journal for Biomedical Optics

Citation
Do-Hyun Kim, Chul-Gyu Song, Ilko K. Ilev, and Jin U. Kang, "Axial-scanning low-coherence interferometer method for noncontact thickness measurement of biological samples," Appl. Opt. 50, 970-974 (2011)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-50-6-970

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