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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 7, Iss. 12 — Dec. 19, 2012

Analysis of noisy dynamic light scattering data using constrained regularization techniques

Xinjun Zhu, Jin Shen, and John C. Thomas  »View Author Affiliations


Applied Optics, Vol. 51, Issue 31, pp. 7537-7548 (2012)
http://dx.doi.org/10.1364/AO.51.007537


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Abstract

Dynamic light scattering (DLS) from colloidal particles often contains noise, which makes inversion of the correlation function to obtain the particle size distribution (PSD) unreliable. In this work, poor-quality correlation function data with baseline error were analyzed using constrained regularization techniques. The effect of baseline error was investigated, and two strategies were proposed to compensate for baseline error. One strategy is based on edge proportion detection of spurious peaks at large size in the PSD, and the other is based on the solution norm. Results from simulated and experimental data demonstrate the effectiveness of our proposed strategies. The L-curve rules for standard Tikhonov and for constrained regularization, the generalized cross-validation (GCV) rule, and the robust GCV rule were investigated for determination of the regularization parameter. A comparison of these rules was done using both simulated and experimental data. It is shown that correction of baseline error with baseline compensation as well as a reasonable regularization parameter choice improves the accuracy of PSD recovery in poor-quality DLS data analysis.

© 2012 Optical Society of America

OCIS Codes
(290.3200) Scattering : Inverse scattering
(290.3700) Scattering : Linewidth
(290.5820) Scattering : Scattering measurements
(290.5850) Scattering : Scattering, particles
(300.6170) Spectroscopy : Spectra

ToC Category:
Instrumentation, Measurement, and Metrology

History
Original Manuscript: May 7, 2012
Revised Manuscript: August 18, 2012
Manuscript Accepted: September 10, 2012
Published: October 24, 2012

Virtual Issues
Vol. 7, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Xinjun Zhu, Jin Shen, and John C. Thomas, "Analysis of noisy dynamic light scattering data using constrained regularization techniques," Appl. Opt. 51, 7537-7548 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-51-31-7537

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