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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 1 — Feb. 4, 2013

Label-free slot-waveguide biosensor for the detection of DNA hybridization

Tuffail Dar, Jiri Homola, B. M. Azizur Rahman, and Muttukrishnan Rajarajan  »View Author Affiliations


Applied Optics, Vol. 51, Issue 34, pp. 8195-8202 (2012)
http://dx.doi.org/10.1364/AO.51.008195


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Abstract

A finite element method based on the full-vectorial H-field formulation has been employed to achieve the maximum field penetration in the sensing medium of the slot-waveguide-based ring resonator biosensor. The use of nanometer scale guiding structure where optical mode is confined in a low-index region permits a very compact sensor with high optical intensity in the region, which makes it possible to detect minimum refractive index change, and offers higher sensitivities. We analyze the change in effective refractive index of mode, sensitivity, and power confinement of the proposed slot-waveguide-based ring resonator biosensor for the detection of DNA hybridization. The biosensor exhibited theoretical sensitivity of 856 nm per refractive index unit (RIU) and a detection limit of 1.43×106RIU.

© 2012 Optical Society of America

OCIS Codes
(130.6010) Integrated optics : Sensors
(230.5750) Optical devices : Resonators
(280.1415) Remote sensing and sensors : Biological sensing and sensors
(160.1435) Materials : Biomaterials
(280.1545) Remote sensing and sensors : Chemical analysis
(280.4788) Remote sensing and sensors : Optical sensing and sensors

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: April 10, 2012
Revised Manuscript: July 26, 2012
Manuscript Accepted: August 27, 2012
Published: November 30, 2012

Virtual Issues
Vol. 8, Iss. 1 Virtual Journal for Biomedical Optics

Citation
Tuffail Dar, Jiri Homola, B. M. Azizur Rahman, and Muttukrishnan Rajarajan, "Label-free slot-waveguide biosensor for the detection of DNA hybridization," Appl. Opt. 51, 8195-8202 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-51-34-8195


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