Optical coherence tomography (OCT) is becoming a popular modality for skin tumor diagnosis and assessment of tumor size and margin status. We conducted a number of imaging experiments on periocular basal cell carcinoma (BCC) specimens using an OCT configuration. This configuration employs a dynamic focus (DF) procedure where the coherence gate moves synchronously with the peak of the confocal gate, which ensures better signal strength and preservation of transversal resolution from all depths. A DF-OCT configuration is used to illustrate morphological differences between the BCC and its surrounding healthy skin in OCT images. The OCT images are correlated with the corresponding histology images. To the best of our knowledge, this is the first paper to look at DF-OCT imaging in examining periocular BCC.
© 2013 Optical Society of America
Original Manuscript: November 8, 2012
Revised Manuscript: February 16, 2013
Manuscript Accepted: February 21, 2013
Published: March 29, 2013
Vol. 8, Iss. 5 Virtual Journal for Biomedical Optics
Mohammad R. N. Avanaki, Ali Hojjatoleslami, Mano Sira, John B. Schofield, Carole Jones, and Adrian Gh. Podoleanu, "Investigation of basal cell carcinoma using dynamic focus optical coherence tomography," Appl. Opt. 52, 2116-2124 (2013)