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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 5 — Jun. 6, 2013

Fiber-optic trap-on-a-chip platform for probing low refractive index contrast biomaterials

Tessa M. Piñón, Alessandro R. Castelli, Linda S. Hirst, and Jay E. Sharping  »View Author Affiliations


Applied Optics, Vol. 52, Issue 11, pp. 2340-2345 (2013)
http://dx.doi.org/10.1364/AO.52.002340


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Abstract

Dual-beam fiber trapping is a versatile technique for manipulating microparticles. We fabricate and evaluate the performance of a compact trap-on-a-chip design and demonstrate, for what we believe is the first time, trapping of low-contrast (m<1.005) lipid vesicles in solution. Counterpropagating fibers are fixed along the chip channel, and we calibrate the trap by optically displacing polystyrene microspheres from the trap center. Measured scattering forces are 3049pN from each beam. Stable trapping and reversible deformation of lipid vesicles is demonstrated under femtonewton trapping forces. This chip has applications in probing a variety of soft biomaterials, such as biological cells, lipid membranes, and protein assemblies.

© 2013 Optical Society of America

OCIS Codes
(140.7010) Lasers and laser optics : Laser trapping
(170.1420) Medical optics and biotechnology : Biology

ToC Category:
Lasers and Laser Optics

History
Original Manuscript: July 10, 2012
Revised Manuscript: January 7, 2013
Manuscript Accepted: March 6, 2013
Published: April 8, 2013

Virtual Issues
Vol. 8, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Tessa M. Piñón, Alessandro R. Castelli, Linda S. Hirst, and Jay E. Sharping, "Fiber-optic trap-on-a-chip platform for probing low refractive index contrast biomaterials," Appl. Opt. 52, 2340-2345 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-52-11-2340


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