OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 5 — Jun. 6, 2013

Study of the effect of mechanical pressure on determination of position and size of tumor in biological phantoms

Mohammad Ali Ansari, Mohsen Erfanzadeh, Saeid Alikhani, and Ezeddin Mohajerani  »View Author Affiliations

Applied Optics, Vol. 52, Issue 12, pp. 2739-2749 (2013)

View Full Text Article

Enhanced HTML    Acrobat PDF (854 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



Diffuse optical tomography (DOT) is an emerging oncological imaging modality that is based on a near-infrared optical technique. DOT provides the spatial volume and depth of tumors by determination of optical properties of biological tissues, such as the absorption and scattering coefficients. During a DOT, the optical fibers are kept in contact with biological tissues that introduce a certain amount of pressure on the local biological tissue. Due to this pressure, the shape of the organ, for instance a breast, deforms. Moreover, this pressure could influence the intrinsic characteristics of the biological tissue. Therefore, pressure can be an important parameter in DOT. In this paper, the effects of pressure on the determination of the size and position of a tumor in biological phantoms are studied. To do so, tissue-like phantoms that are made of intralipid, Indian ink, and agar are constructed. Defects with optical properties similar to those of tumors are placed inside the phantoms. Then various values of pressure are applied to the phantoms. Subsequently, the optical properties of phantoms as well as the position and size of the tumor are reconstructed by inverse models based on the boundary integral method. The variations of reconstructed data induced by pressure are studied. The results demonstrate that pressure causes an increase in the scattering coefficient.

© 2013 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3660) Medical optics and biotechnology : Light propagation in tissues

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: October 11, 2012
Revised Manuscript: January 7, 2013
Manuscript Accepted: March 6, 2013
Published: April 17, 2013

Virtual Issues
Vol. 8, Iss. 5 Virtual Journal for Biomedical Optics

Mohammad Ali Ansari, Mohsen Erfanzadeh, Saeid Alikhani, and Ezeddin Mohajerani, "Study of the effect of mechanical pressure on determination of position and size of tumor in biological phantoms," Appl. Opt. 52, 2739-2749 (2013)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. N. H. Neimz, Laser-Tissue Interaction: Fundamentals and Applications (Springer-Verlag, 2003).
  2. V. Tuchin, Tissue Optics Light Scattering Methods and Instruments for Medical Diagnosis, 2nd ed. (SPIE, 2007).
  3. N. Gosh, S. K. Mohanty, S. K. Majumder, and P. K. Gupta, “Measurement of optical transport properties of normal and malignant human breast tissue,” Appl. Opt 40, 176–184 (2001). [CrossRef]
  4. E. Salomatina, “Optical properties of normal and cancerous human skin in the visible and near infrared spectral range,” J. Biomed. Opt. 11, 064026 (2006). [CrossRef]
  5. L. V. Wang and H. I. Wu, Biomedical Optics: Principle and Imaging (Wiley, 2007).
  6. N. Iftimia, W. R. Brugge, and D. X. Hammer, Advances in Optical Imaging for Clinical Medicine (Wiley, 2011).
  7. H. Shangguan, S. A. Prahl, S. L. Jacques, L. W. Casperson, and K. W. Gregory, “Pressure effects on soft tissues monitored by changes in tissue optical properties,” Proc. SPIE 3254, 366–371 (1998). [CrossRef]
  8. Y. Ti and W. C. Lin, “Effects of probe contact pressure on in vivo optical spectroscopy,” Opt. Express 16, 4250–4262(2008). [CrossRef]
  9. G. Z. Chen, Y. X. Xu, Y. H. Wang, H. Q. Yang, Q. Y. Lin, L. J. Li, Z. Y. Guo, and S. H. Liu, “Optical transport properties along the pericardium meridian under different pressure,” J. Lasers Med. Sci. 2, 89–97 (2011).
  10. H. Dehghani, M. M. Doyley, B. W. Pogue, S. Jiang, J. Geng, and K. D. Paulsen, “Breast deformation modelling for image reconstruction in near infrared optical tomography,” Phys. Med. Biol. 49, 1131–1145 (2004). [CrossRef]
  11. S. D. Jiang, B. W. Pogue, and K. D. Paulsen, “In vivo near-infrared spectral detection of pressure-induced changes in breast tissue,” Opt. Lett. 28, 1212–1214 (2003). [CrossRef]
  12. P. Pathmanathan, D. J. Gavaghan, J. P. Whiteley, S. J. Chapman, and J. M. Brady, “Predicting tumor location by modeling the deformation of breast,” IEEE Trans. Biomed. Eng. 55, 2471–2480 (2008). [CrossRef]
  13. Z. Wang, “Mechanical and optical methods for breast cancer imaging,” Ph.D. dissertation (Iowa University, 2010).
  14. M. A. Ansari, S. Alikhani, E. Mohajerani, and R. Massudi, “The numerical and experimental study of photon diffusion inside biological tissue using boundary integral method,” Opt. Commun. 285, 851–855 (2012). [CrossRef]
  15. M. A. Ansari, and R. Massudi, “Study of short pulse laser propagation in biological tissue by means of boundary element method,” Lasers Med. Sci. 26, 503–508 (2011). [CrossRef]
  16. M. A. Ansari, R. Massudi, and M. Hejazi, “Experimental and numerical study on simultaneous effects of scattering and absorption on fluorescence spectroscopy of a breast phantom,” Opt. Laser Technol. 41, 746–750 (2009). [CrossRef]
  17. M. Schweiger, S. R. Arridge, M. Hiraoka, and D. T. Delphy, “The finite element method for propagation of light in scattering media: boundary and source conditions,” Med. Phys. 22, 1779–1791 (1995). [CrossRef]
  18. M. A. Ansari and R. Massudi, “The boundary integral method for simulating laser short pulse penetration into biological tissues,” J. Biomed. Opt. 15, 065009 (2010). [CrossRef]
  19. S. Srinivasan, B. W. Pogue, C. Carpenter, P. K. Yalavarthy, and K. Paulsen, “A boundary element approach for image-guided near-infrared absorption and scatter estimation,” Med. Phys. 34, 4545–4557 (2007). [CrossRef]
  20. S. Srinivasan, H. R. Ghadyani, B. W. Pogue, and K. D. Paulsen, “A coupled finite element-boundary element method for modeling diffusion equation in 3D multi-modality optical imaging,” Biomed. Opt. Express 1, 398–413 (2010). [CrossRef]
  21. C. Bonnery, P. O. Leclerc, M. Desjardins, R. Hoge, L. Bherer, P. Pouliot, and F. Lesage, “Changes in diffusion path length with old age in diffuse optical tomography,” J. Biomed. Opt 17, 056002 (2012). [CrossRef]
  22. H. Jiang, Diffuse Optical Tomography: Principles and Applications (CRC, 2011).
  23. S. R. Arridge, “Optical tomography in medical imaging,” Inverse Probl. 15, R41–R93 (1999). [CrossRef]
  24. R. Choe, “Diffuse optical tomography and spectroscopy of breast cancer and fetal brain,” Ph.D. thesis (Department of Physics and Astronomy, University of Pennsylvania, 2005).
  25. V. G. Peters, D. R. Wymant, M. S. Patterson, and G. L. Frank, “Optical properties of normal and diseased human breast tissues in the visible and near infrared,” Phys. Med. Biol. 35, 1317–1334 (1990). [CrossRef]
  26. B. J. Tromberg, O. C. Uoz, J. B. Fishkin, T. Pham, E. R. Anderson, J. Butler, M. Cahn, J. D. Gross, V. Venugopalan, and D. Pham, “Non-invasive measurements of breast tissue optical properties using frequency-domain photon migration,” Phil. Trans. R. Soc. B 352, 661–668 (1997). [CrossRef]
  27. M. Erfanzadeh, S. Alikhani, M. A. Ansari, and E. Mohajerani, “A low-cost method for optical tomography,” J. Lasers Med. Sci. 3, 102–108 (2012).
  28. C. Li, S. Li, G. Guan, C. Wei, Z. Huang, and R. K. Wang, “A comparison of laser ultrasound measurements and finite element simulations for evaluating the elastic properties of tissue mimicking phantoms,” Opt. Laser Technol. 44, 866–871 (2012). [CrossRef]
  29. A. J. Welch and M. V. C. Gemert, Optical-Response of Laser-Irradiated Tissue (Springer, 1995).
  30. F. S. Azar, D. N. Metaxas, and M. D. Schnall, “A deformable finite element model of the breast for predicting mechanical deformations under external perturbations,” Acad. Radiol. 8, 965–975 (2001). [CrossRef]
  31. K. E. Chan, B. Sorg, D. Protsenko, M. O’Neil, M. Motamedi, and A. J. Welch, “Effects of compression on soft tissue optical properties,” IEEE J. Sel. Top. Quantum Electron. 2, 943–950 (1996). [CrossRef]
  32. J. H. Chung, V. Rajagopal, P. M. F. Nielsen, and M. P. Nash, “Modeling mammographic compression of the breast,” Lect. Notes Comput. Sci. 5242, 758–765 (2008). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited