OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 7 — Aug. 1, 2013

Full-field optical coherence tomography using immersion Mirau interference microscope

Sheng-Hua Lu, Chia-Jung Chang, and Ching-Fen Kao  »View Author Affiliations

Applied Optics, Vol. 52, Issue 18, pp. 4400-4403 (2013)

View Full Text Article

Enhanced HTML    Acrobat PDF (423 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools



In this study, an immersion Mirau interference microscope was developed for full-field optical coherence tomography (FFOCT). Both the reference and measuring arms of the Mirau interferometer were filled with water to prevent the problems associated with imaging a sample in air with conventional FFOCT systems. The almost-common path interferometer makes the tomographic system less sensitive to environmental disturbances. En face OCT images at various depths were obtained with phase-shifting interferometry and Hariharan algorithm. This immersion interferometric method improves depth and quality in three-dimensional OCT imaging of scattering tissue.

© 2013 Optical Society of America

OCIS Codes
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(180.3170) Microscopy : Interference microscopy

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: April 23, 2013
Manuscript Accepted: May 20, 2013
Published: June 19, 2013

Virtual Issues
Vol. 8, Iss. 7 Virtual Journal for Biomedical Optics

Sheng-Hua Lu, Chia-Jung Chang, and Ching-Fen Kao, "Full-field optical coherence tomography using immersion Mirau interference microscope," Appl. Opt. 52, 4400-4403 (2013)

Sort:  Author  |  Year  |  Journal  |  Reset  


  1. A. Dubois and A. C. Boccara, “Full-field optical coherence tomography,” in Optical Coherence Tomography, W. Drexler and J. G. Fujimoto, eds. (Springer-Verlag, 2008), pp. 565–591.
  2. B. Bhushan, J. C. Wyant, and C. L. Koliopoulos, “Measurement of surface topography of magnetic tapes by Mirau interferometry,” Appl. Opt. 24, 1489–1497 (1985). [CrossRef]
  3. A. Dubois, L. Vabre, A.-C. Boccara, and E. Beaurepaire, “High-resolution full-field optical coherence tomography with a Linnik microscope,” Appl. Opt. 41, 805–812 (2002). [CrossRef]
  4. J. Moreau, V. Loriette, and A. Boccara, “Full-field birefringence imaging by thermal-light polarization-sensitive optical coherence tomography. I: theory,” Appl. Opt. 42, 3800–3810 (2003). [CrossRef]
  5. Y. Watanabe, Y. Hayasaka, M. Sato, and N. Tanno, “Full-field optical coherence tomography by achromatic phase shifting with a rotating polarizer,” Appl. Opt. 44, 1387–1392 (2005). [CrossRef]
  6. M. S. Hrebesh, R. Dabu, and M. Sato, “In vivo imaging of dynamic biological specimen by real-time single-shot full-field optical coherence tomography,” Opt. Commun. 282, 674–683 (2009). [CrossRef]
  7. S. H. Lu, C. Y. Wang, C. Y. Hsieh, K. Y. Chiu, and H. Y. Chen, “Full-field optical coherence tomography using nematic liquid-crystal phase shifter,” Appl. Opt. 51, 1361–1366 (2012). [CrossRef]
  8. E. Beaurepaire, A. C. Boccara, M. Lebec, L. Blanchot, and H. Saint-Jalmes, “Full-field optical coherence microscopy,” Opt. Lett. 23, 244–246 (1998). [CrossRef]
  9. J. Reed, M. Frank, J. K. Gimzewski, J. J Troke, J. Schmit, S. Han, M. A Teitell, and J. K Gimzewski, “High throughput cell nanomechanics with mechanical imaging interferometry,” Nanotechnology 19, 235101 (2008). [CrossRef]
  10. G. Latour, J.-P. Echard, B. Soulier, I. Emond, S. Vaiedelich, and M. Elias, “Structural and optical properties of wood and wood finishes studied using optical coherence tomography: application to an 18th century Italian violin,” Appl. Opt. 48, 6485–6491 (2009). [CrossRef]
  11. T. Anna, V. Srivastava, D. S. Mehta, and C. Shakher, “High-resolution full-field optical coherence microscopy using a Mirau interferometer for the quantitative imaging of biological cells,” Appl. Opt. 50, 6343–6351 (2011). [CrossRef]
  12. O. V. Lyulko, G. Randers-Pehrson, and D. J. Brenner, “Immersion Mirau interferometry for label-free live cell imaging in an epi-illumination geometry,” Proc. SPIE 7568, 756825 (2010). [CrossRef]
  13. H. Schreiber and J. H. Bruning, “Phase shifting interferometry,” in Optical Shop Testing, D. Malacara, ed., 3rd ed. (Wiley, 2007), pp. 547–666.

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited