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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 10 — Nov. 8, 2013

Imaging system to assess objectively the optical density of the macular pigment in vivo

Andrew O’Brien, Conor Leahy, and Chris Dainty  »View Author Affiliations


Applied Optics, Vol. 52, Issue 25, pp. 6201-6212 (2013)
http://dx.doi.org/10.1364/AO.52.006201


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Abstract

This paper presents an optical system called MacPI, which implements a two-color reflectance technique in combination with various hardware and software tools to assess objectively the macular pigment (MP) optical density in vivo. The system consists of a bespoke optical design, a control architecture, driver electronics, a collection of image-processing techniques, and a graphical user interface. The deficiencies of the technique employed and the solutions implemented in the MacPI system to confront those inherent frailties are presented. An overview of the effective interpretation of the acquired data and the techniques employed by MacPI in the acquisition of that data is discussed. The result of a comparison trial with an alternative device is also presented. We suggest that appropriate design of the hardware and an efficient interpretation of the acquired data should produce a system capable of consistent, accurate, and rapid measurements, while retaining the distinction of ease of use, portability, comfort for the subject, and a design that is economic to produce. Its versatility should allow both for a clinical screening application and for further investigation and establishment of the physiological role of the MP in a laboratory-based environment.

© 2013 Optical Society of America

OCIS Codes
(100.0100) Image processing : Image processing
(170.0110) Medical optics and biotechnology : Imaging systems
(330.4460) Vision, color, and visual optics : Ophthalmic optics and devices
(330.7310) Vision, color, and visual optics : Vision

ToC Category:
Image Processing

History
Original Manuscript: May 16, 2013
Manuscript Accepted: June 27, 2013
Published: August 23, 2013

Virtual Issues
Vol. 8, Iss. 10 Virtual Journal for Biomedical Optics

Citation
Andrew O’Brien, Conor Leahy, and Chris Dainty, "Imaging system to assess objectively the optical density of the macular pigment in vivo," Appl. Opt. 52, 6201-6212 (2013)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-52-25-6201


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