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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 8, Iss. 4 — May. 22, 2013

Combined photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source

Changho Lee, Seunghoon Han, Sehui Kim, Mansik Jeon, Min Yong Jeon, Chulhong Kim, and Jeehyun Kim  »View Author Affiliations

Applied Optics, Vol. 52, Issue 9, pp. 1824-1828 (2013)

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We developed an integrated dual-modal photoacoustic and optical coherence tomography (PA-OCT) system using a single near-infrared supercontinuum laser source to simultaneously provide both optical absorption and scattering contrasts. A pulsed broadband supercontinuum source was generated by a pulsed Nd:YAG laser and a photonic-crystal fiber. When we imaged two colored hairs, the black hair was visible in both PA and OCT images, whereas the white hair was only mapped in the OCT image. The single laser source will potentially allow us to implement relatively simple, cheap, and compact dual-modal PA-OCT systems, which are key criteria for fast clinical translation and commercialization.

© 2013 Optical Society of America

OCIS Codes
(170.0110) Medical optics and biotechnology : Imaging systems
(170.0170) Medical optics and biotechnology : Medical optics and biotechnology
(170.4500) Medical optics and biotechnology : Optical coherence tomography
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Imaging Systems

Original Manuscript: September 27, 2012
Revised Manuscript: November 27, 2012
Manuscript Accepted: January 13, 2013
Published: March 13, 2013

Virtual Issues
Vol. 8, Iss. 4 Virtual Journal for Biomedical Optics

Changho Lee, Seunghoon Han, Sehui Kim, Mansik Jeon, Min Yong Jeon, Chulhong Kim, and Jeehyun Kim, "Combined photoacoustic and optical coherence tomography using a single near-infrared supercontinuum laser source," Appl. Opt. 52, 1824-1828 (2013)

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  1. C. Kim, C. Favazza, and L. V. Wang, “In vivo photoacoustic tomography of chemicals: high-resolution functional and molecular optical imaging at new depths,” Chem. Rev. 110, 2756–2782 (2010). [CrossRef]
  2. K. Maslov, H. F. Zhang, S. Hu, and L. V. Wang, “Optical-resolution photoacoustic microscopy for in vivo imaging of single capillaries,” Opt. Lett. 33, 929–931 (2008). [CrossRef]
  3. H. F. Zhang, K. Maslov, G. Stoica, and L. V. Wang, “Functional photoacoustic microscopy for high-resolution and noninvasive in vivo imaging,” Nat. Biotechnol. 24, 848–851 (2006). [CrossRef]
  4. M. Heijblom, D. Piras, W. Xia, J. C. van Hespen, J. M. Klaase, F. M. van den Engh, T. G. van Leeuwen, W. Steenbergen, and S. Manohar, “Visualizing breast cancer using the Twente photoacoustic mammoscope: what do we learn from twelve new patient measurements?” Opt. Express 20, 11582–11597 (2012). [CrossRef]
  5. C. Kim, E. C. Cho, J. Chen, K. H. Song, L. Au, C. Favazza, Q. Zhang, C. M. Cobley, F. Gao, Y. Xia, and L. V. Wang, “In vivo molecular photoacoustic tomography of melanomas targeted by bioconjugated gold nanocages,” ACS Nano 4, 4559–4564 (2010). [CrossRef]
  6. J. Yao, K. I. Maslov, and L. V. Wang, “In vivo photoacoustic tomography of total blood flow and potential imaging of cancer angiogenesis and hypermetabolism,” Technol. Cancer Res. Treat. 11, 301–307 (2012). [CrossRef]
  7. S. Hu, K. Maslov, V. Tsytsarev, and L. V. Wang, “Functional transcranial brain imaging by optical-resolution photoacoustic microscopy,” J. Biomed. Opt. 14, 040503 (2009). [CrossRef]
  8. J. Laufer, E. Zhang, G. Raivich, and P. Beard, “Three-dimensional noninvasive imaging of the vasculature in the mouse brain using a high resolution photoacoustic scanner,” Appl. Opt. 48, D299–D306 (2009). [CrossRef]
  9. E. W. Stein, K. Maslov, and L. V. Wang, “Noninvasive, in vivo imaging of blood-oxygenation dynamics within the mouse brain using photoacoustic microscopy,” J. Biomed. Opt. 14, 020502 (2009). [CrossRef]
  10. M. Jeon and C. Kim, “Multimodal photoacoustic tomography,” IEEE Trans. Multimedia, in press.
  11. C. Kim, T. N. Erpelding, L. Jankovic, and L. V. Wang, “Performance benchmarks of an array-based hand-held photoacoustic probe adapted from a clinical ultrasound system for non-invasive sentinel lymph node imaging,” Phil. Trans. R. Soc. A 369, 4644–4650 (2011). [CrossRef]
  12. W. J. Akers, C. Kim, M. Berezin, K. Guo, R. Fuhrhop, G. M. Lanza, G. M. Fischer, E. Daltrozzo, A. Zumbusch, X. Cai, L. V. Wang, and S. Achilefu, “Noninvasive photoacoustic and fluorescence sentinel lymph node identification using dye-loaded perfluorocarbon nanoparticles,” ACS Nano 5, 173–182 (2011). [CrossRef]
  13. Y. Wang, K. Maslov, C. Kim, S. Hu, and L. V. Wang, “Integrated photoacoustic and fluorescence confocal microscopy,” IEEE Trans. Bio-med. Eng. 57, 2576–2578 (2010). [CrossRef]
  14. C. Kim, K. H. Song, F. Gao, and L. V. Wang, “Sentinel lymph nodes and lymphatic vessels: noninvasive dual-modality in vivo mapping by using indocyanine green in rats—volumetric spectroscopic photoacoustic imaging and planar fluorescence imaging,” Radiology 255, 442–450 (2010). [CrossRef]
  15. E. Z. Zhang, B. Povazay, J. Laufer, A. Alex, B. Hofer, B. Pedley, C. Glittenberg, B. Treeby, B. Cox, P. Beard, and W. Drexler, “Multimodal photoacoustic and optical coherence tomography scanner using an all optical detection scheme for 3D morphological skin imaging,” Biomed. Opt. Express 2, 2202–2215 (2011). [CrossRef]
  16. L. Li, K. Maslov, G. Ku, and L. V. Wang, “Three-dimensional combined photoacoustic and optical coherence microscopy for in vivo microcirculation studies,” Opt. Express 17, 16450–16455 (2009). [CrossRef]
  17. S. Jiao, Z. Xie, H. F. Zhang, and C. A. Puliafito, “Simultaneous multimodal imaging with integrated photoacoustic microscopy and optical coherence tomography,” Opt. Lett. 34, 2961–2963 (2009). [CrossRef]
  18. W. Song, Q. Wei, T. Liu, D. Kuai, J. M. Burke, S. Jiao, and H. F. Zhang, “Integrating photoacoustic ophthalmoscopy with scanning laser ophthalmoscopy, optical coherence tomography, and fluorescein angiography for a multimodal retinal imaging platform,” J. Biomed. Opt. 17, 061206 (2012). [CrossRef]
  19. X. Zhang, H. F. Zhang, and S. Jiao, “Optical coherence photoacoustic microscopy: accomplishing optical coherence tomography and photoacoustic microscopy with a single light source,” J. Biomed. Opt. 17, 030502 (2012). [CrossRef]
  20. Y. N. Billeh, M. Liu, and T. Buma, “Spectroscopic photoacoustic microscopy using a photonic crystal fiber supercontinuum source,” Opt. Express 18, 18519–18524 (2010). [CrossRef]
  21. W. Wadsworth, N. Joly, J. Knight, T. Birks, F. Biancalana, and P. Russell, “Supercontinuum and four-wave mixing with Q-switched pulses in endlessly single-mode photonic crystal fibres,” Opt. Express 12, 299–309 (2004). [CrossRef]
  22. R. J. Thomas, B. A. Rockwell, W. J. Marshall, R. C. Aldrich, S. A. Zimmerman, and R. J. Rockwell, “A procedure for laser hazard classification under the Z136.1-2000 American National Standard for safe use of lasers,” J. Laser Appl. 14, 57–66 (2002). [CrossRef]
  23. A. C. Santos Nogueira and I. Joekes, “Hair color changes and protein damage caused by ultraviolet radiation,” J. Photochem. Photobiol. B 74, 109–117 (2004). [CrossRef]
  24. Y. Yang, X. Li, T. Wang, P. D. Kumavor, A. Aguirre, K. K. Shung, Q. Zhou, M. Sanders, M. Brewer, and Q. Zhu, “Integrated optical coherence tomography, ultrasound and photoacoustic imaging for ovarian tissue characterization,” Biomed. Opt. Express 2, 2551–2561 (2011). [CrossRef]
  25. M. Jeon, J. Kim, U. Jung, C. Lee, W. Jung, and S. A. Boppart, “Full-range k-domain linearization in spectral-domain optical coherence tomography,” Appl. Opt. 50, 1158–1163 (2011). [CrossRef]
  26. L. Wang, K. Maslov, J. Yao, B. Rao, and L. V. Wang, “Fast voice-coil scanning optical-resolution photoacoustic microscopy,” Opt. Lett. 36, 139–141 (2011). [CrossRef]

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