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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 9, Iss. 4 — Apr. 1, 2014

Compact, high-resolution, self-referenced, optical activity polarimeter for high-pressure liquid chromatography systems

Doron Goldberg and Zeev Weissman  »View Author Affiliations


Applied Optics, Vol. 53, Issue 4, pp. 577-587 (2014)
http://dx.doi.org/10.1364/AO.53.000577


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Abstract

Optical rotation (OR) polarimeters measure only the OR of a linearly polarized wave vector caused by the optical activity of the measured material. Such polarimeters are used to detect optically active materials and measure their concentration. Here we describe a novel type of high-resolution OR polarimeter. The new polarimeter is a compact device, based on a combination of two novel mechanisms: a referencing mechanism and an optical signal-gain mechanism. The patented referencing mechanism allows accurate measurements of small ORs in the presence of considerable polarization noise. The current limit of detection of the polarimeter is 20 micro-degrees, which we believe can be lowered further. The polarimeter is intended to serve as an add-on detector for existing high-pressure liquid chromatography (HPLC) systems in the pharmaceutical industry. The need for such a polarimeter, its optical setup, analysis of its performance, and experimental results are hereby given and discussed.

© 2014 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(120.5410) Instrumentation, measurement, and metrology : Polarimetry
(260.5430) Physical optics : Polarization

ToC Category:
Instrumentation, Measurement, and Metrology

History
Original Manuscript: October 18, 2013
Manuscript Accepted: December 10, 2013
Published: January 24, 2014

Virtual Issues
Vol. 9, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Doron Goldberg and Zeev Weissman, "Compact, high-resolution, self-referenced, optical activity polarimeter for high-pressure liquid chromatography systems," Appl. Opt. 53, 577-587 (2014)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-53-4-577


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