OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 9, Iss. 4 — Apr. 1, 2014

Compact, high-resolution, self-referenced, optical activity polarimeter for high-pressure liquid chromatography systems

Doron Goldberg and Zeev Weissman  »View Author Affiliations


Applied Optics, Vol. 53, Issue 4, pp. 577-587 (2014)
http://dx.doi.org/10.1364/AO.53.000577


View Full Text Article

Enhanced HTML    Acrobat PDF (1233 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Optical rotation (OR) polarimeters measure only the OR of a linearly polarized wave vector caused by the optical activity of the measured material. Such polarimeters are used to detect optically active materials and measure their concentration. Here we describe a novel type of high-resolution OR polarimeter. The new polarimeter is a compact device, based on a combination of two novel mechanisms: a referencing mechanism and an optical signal-gain mechanism. The patented referencing mechanism allows accurate measurements of small ORs in the presence of considerable polarization noise. The current limit of detection of the polarimeter is 20 micro-degrees, which we believe can be lowered further. The polarimeter is intended to serve as an add-on detector for existing high-pressure liquid chromatography (HPLC) systems in the pharmaceutical industry. The need for such a polarimeter, its optical setup, analysis of its performance, and experimental results are hereby given and discussed.

© 2014 Optical Society of America

OCIS Codes
(120.3890) Instrumentation, measurement, and metrology : Medical optics instrumentation
(120.5410) Instrumentation, measurement, and metrology : Polarimetry
(260.5430) Physical optics : Polarization

ToC Category:
Instrumentation, Measurement, and Metrology

History
Original Manuscript: October 18, 2013
Manuscript Accepted: December 10, 2013
Published: January 24, 2014

Virtual Issues
Vol. 9, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Doron Goldberg and Zeev Weissman, "Compact, high-resolution, self-referenced, optical activity polarimeter for high-pressure liquid chromatography systems," Appl. Opt. 53, 577-587 (2014)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=ao-53-4-577

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited