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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 9 — Sep. 26, 2007

Single Nanoparticle Based Optical pH Probe

Rebecca A. Jensen, Jennifer Sherin, and Steven R. Emory

Applied Spectroscopy, Vol. 61, Issue 8, pp. 832-838 (2007)

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This paper describes the development of a nanoscale optical pH probe based upon the surface-enhanced Raman scattering (SERS) properties of silica–gold core-shell nanoparticles. In this approach, a thin layer of gold is deposited onto a core of silica to form a metallic nanoshell with surface plasmon modes in the red-to-near-infrared spectral region. The surface of the nanoshell is functionalized with a pH-sensitive SERS reporter molecule, 4-mercaptopyridine (4-MPy). The SERS spectra of 4-MPy is shown to be sensitive to the pH of the surrounding media within the range of 3 to 7. In addition, it is shown that individual silica–gold core-shell nanoparticles yield more reliable SERS spectra than aggregates of core-shell nanoparticles.

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Vol. 2, Iss. 9 Virtual Journal for Biomedical Optics

Rebecca A. Jensen, Jennifer Sherin, and Steven R. Emory, "Single Nanoparticle Based Optical pH Probe," Appl. Spectrosc. 61, 832-838 (2007)

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