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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 12 — Dec. 1, 2008

Polarized Raman Microspectroscopy Can Reveal Structural Changes of Peritumoral Dermis in Basal Cell Carcinoma

Elodie Ly, Olivier Piot, Anne Durlach, Philippe Bernard, and Michel Manfait

Applied Spectroscopy, Vol. 62, Issue 10, pp. 1088-1094 (2008)


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Abstract

Polarized Raman microspectroscopy can provide precious information regarding the orientation and ordering of the molecules in a sample without staining or particular preparation. This technique is used for the first time on a human skin section to probe the molecular modifications of the surrounding dermis in superficial basal cell carcinoma. Spectra using polarized and conventional Raman microspectroscopies were recorded on dermis bordering either the tumor or healthy epidermis. Band areas and spectral decomposition on selected vibrations were computed. Significant differences in dermal collagen vibration bands are detected using both polarized and conventional micro-spectroscopies, but the spectral changes between tumor and healthy tissues are enhanced using polarized Raman microspectroscopy. The analysis of these spectral differences highlights structural modifications of the triple helix of collagen. We see polarized Raman microspectroscopy as a potential tool that could be implemented for clinical analyses to guide clinicians and surgeons in the treatment of aggressive skin cancers. The information obtainable could also help better elucidate the molecular mechanisms induced in basal cell carcinoma development.

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Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics

Citation
Elodie Ly, Olivier Piot, Anne Durlach, Philippe Bernard, and Michel Manfait, "Polarized Raman Microspectroscopy Can Reveal Structural Changes of Peritumoral Dermis in Basal Cell Carcinoma," Appl. Spectrosc. 62, 1088-1094 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=as-62-10-1088

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