Multiplicative scatter correction (MSC) is a widely used normalization technique. It aims to correct spectra in such a way that they are as close as possible to a reference spectrum, generally the mean of the data set, by changing the scale and the offset of the spectra. When there are other differences in the spectra than just a scale and an offset, the mean spectrum changes after MSC. As a result, another MSC, with the new mean spectrum as the reference, will result in an additional correction. This paper studies the effect of multiple applications of MSC.
Vol. 3, Iss. 12 Virtual Journal for Biomedical Optics
Willem Windig, Jeremy Shaver, and Rasmus Bro, "Loopy MSC: A Simple Way to Improve Multiplicative Scatter Correction," Appl. Spectrosc. 62, 1153-1159 (2008)