Rhodamine 6G (R6G) doped thin films composed of poly(L-lactic acid) (PLLA) and Pluronic P104 were spin cast onto glass microscope slides and characterized by ultraviolet–visible, steady-state, and time-resolved fluorescence spectroscopy. The results show that R6G aggregation within the film increases as the R6G concentration and P104 loading increases. These results suggest an approach for studying drug distributions (monomers, aggregates) within biodegradable polymer formulations.
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics
Jordan M. Steves, Loraine T. Tan, Joseph A. Gardella, Robert Hard, Wesley L. Hicks, Alexander N. Cartwright, Bahattan Koc, and Frank V. Bright, "Guest Aggregation Within Poly(L-lactic acid)/Pluronic P104 Thin Films," Appl. Spectrosc. 62, 290-294 (2008)