OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

Fiber-Optic Infrared Reflection Absorption Spectroscopy for Trace Analysis on Surfaces of Varying Roughness. Part II: Acetaminophen on Stainless Steel

Benjamin B. Perston, Michelle L. Hamilton, Peter W. Harland, Mary A. Thomson, Peter J. Melling, and Bryce E. Williamson

Applied Spectroscopy, Vol. 62, Issue 3, pp. 312-318 (2008)


View Full Text Article

Acrobat PDF (906 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations
  • Export Citation/Save Click for help

Abstract

Investigations of the effects of surface roughness on the utility of grazing-angle Fourier transform infrared reflection absorption spectroscopy (IRRAS) as a method for quantifying trace contamination of metal surfaces have been extended to acetaminophen, a model active pharmaceutical agent, on 316 stainless steel. The effects are more complicated than for the surfactant sodium dodecyl sulfate (SDS) on stainless steel; they include a strong surface-finish dependence of sensitivity and nonlinear behavior at surface loadings above ∼1–2 μg cm−2. Using data from samples in the loading range 0–0.5 μg cm−2, unbiased partial least squared calibrations can be readily achieved for individual surface finishes with detection limits of LD ≈ 0.15 μg cm−2. However, as found for SDS on stainless steel, models built using data from samples of mixed surface roughness are more problematic.

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Benjamin B. Perston, Michelle L. Hamilton, Peter W. Harland, Mary A. Thomson, Peter J. Melling, and Bryce E. Williamson, "Fiber-Optic Infrared Reflection Absorption Spectroscopy for Trace Analysis on Surfaces of Varying Roughness. Part II: Acetaminophen on Stainless Steel," Appl. Spectrosc. 62, 312-318 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=as-62-3-312

You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.

Contact your librarian or system administrator
or
Log in to access OSA Member Subscription

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited