OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 6 — May. 26, 2009

Modified Local Straight-Line Screening to Detect Synthetic Drugs in Adulterated Herbal Medicines

Zhu Xueyi, Zhang Zhonghu, Lu Feng, Wu Yutian, and Qi Yunpeng

Applied Spectroscopy, Vol. 63, Issue 4, pp. 471-476 (2009)

View Full Text Article

Acrobat PDF (275 KB)

Browse Journals / Lookup Meetings

Browse by Journal and Year


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

  • Export Citation/Save Click for help


A local straight-line screening (LSLS) algorithm was recently designed as a method to detect synthetic drug(s) in adulterated herbal medicines based on infrared spectroscopy. Some modifications are made in this paper to improve the existing LSLS algorithm, including interpolation, second derivation, and change of calculation regions from 3 to 7 data points. These modifications have decreased the effect of unpredicted noises and baseline shift on infrared spectroscopy, resulting in outstanding detailed spectral characteristics of the suspected synthetic drugs. The algorithm has been tested using five kinds of synthetic drugs (sibutramine, fenfluramine, lovastatin, sildenafil, and methyldopa) in 40 herbal medicine samples. The concentration of the synthetic drug(s) predicted by the modified LSLS algorithm is closer to those determined by high-performance liquid chromatography. Consequently, the correct results rise from 30 obtained using the original LSLS to 36 obtained using the modified LSLS in 40 samples, the false negative responses drop from 5 to 1, and the false positive responses drop from 5 to 3. The results obtained using the M-LSLS algorithm based on the sibutramine spectrum collected at different times and on different instruments also vary within acceptable ranges. These allow the method to be more appropriate for the preliminary screening of herbal medicines suspected of adulteration with synthetic drugs, with high rapidity, accuracy, and cost effectiveness.

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Zhu Xueyi, Zhang Zhonghu, Lu Feng, Wu Yutian, and Qi Yunpeng, "Modified Local Straight-Line Screening to Detect Synthetic Drugs in Adulterated Herbal Medicines," Appl. Spectrosc. 63, 471-476 (2009)

Sort:  Journal  |  Reset


References are not available for this paper.

Cited By

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited