The detection and identification of biologically important molecules has critical importance in several fields such as medicine, biotechnology, and pharmacology. Surface-enhanced Raman scattering (SERS) is a powerful emerging vibrational spectroscopic technique that allows not only for the characterization, but also for the identification and detection of biomacromolecules in a very short time. In this review, efforts to utilize SERS for label-free protein detection and identification is summarized after a short introduction of proteins and the technique.
Vol. 8, Iss. 5 Virtual Journal for Biomedical Optics
Mustafa Culha, "Surface-Enhanced Raman Scattering: An Emerging Label-Free Detection and Identification Technique for Proteins," Appl. Spectrosc. 67, 355-364 (2013)