Abstract

The size-dependent interactions of eight blood proteins with silver nanoparticles (AgNPs) in their binary mixtures were investigated using surface-enhanced Raman scattering (SERS). Principal component analysis (PCA) was performed on the SERS spectra of each binary mixture, and the differentiation ability of the mixtures was tested. It was found that the effect of relative concentration change on the SERS spectra of the binary mixtures of small proteins could be detected using PCA. However, this change was not observed with the binary mixtures of large proteins. This study demonstrated that the relative interactions of the smaller proteins with an average size of 50 nm AgNPs smaller than the large proteins could be monitored, and this information can be used for the detection of proteins in protein mixtures.

Deterministic aperiodic arrays of metal nanoparticles for surface-enhanced Raman scattering (SERS)

Ashwin Gopinath, Svetlana V. Boriskina, Bjorn M. Reinhard, and Luca Dal Negro
Opt. Express 17(5) 3741-3753 (2009)

Colorectal cancer detection by gold nanoparticle based surface-enhanced Raman spectroscopy of blood serum and statistical analysis

Duo Lin, Shangyuan Feng, Jianji Pan, Yanping Chen, Juqiang Lin, Guannan Chen, Shusen Xie, Haishan Zeng, and Rong Chen
Opt. Express 19(14) 13565-13577 (2011)

Reagent- and separation-free measurements of urine creatinine concentration using stamping surface enhanced Raman scattering (S-SERS)

Ming Li, Yong Du, Fusheng Zhao, Jianbo Zeng, Chandra Mohan, and Wei-Chuan Shih
Biomed. Opt. Express 6(3) 849-858 (2015)

High-performance surface-enhanced Raman scattering substrate prepared by self-assembling of silver nanoparticles into the nanogaps of silver nanoislands

Jiamin Quan, Yong Zhu, Jie Zhang, Junyin Li, and Ning Wang
Appl. Opt. 56(20) 5751-5760 (2017)

Hollow core photonic crystal fiber for monitoring leukemia cells using surface enhanced Raman scattering (SERS)

Altaf Khetani, Ali Momenpour, Emilio I. Alarcon, and Hanan Anis
Biomed. Opt. Express 6(11) 4599-4609 (2015)