4Pi spectral self-interference microscopy
JOSA A, Vol. 24, Issue 12, pp. 3762-3771 (2007)
http://dx.doi.org/10.1364/JOSAA.24.003762
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Abstract
Spectral self-interference microscopy (SSM) relies on the balanced collection of light traveling two different paths from the sample to the detector, one direct and the other indirect from a reflecting substrate. The resulting spectral interference effects allow nanometer-scale axial localization of isolated emitters. To produce spectral fringes the difference between the two optical paths must be significant. Consequently, to ensure that both contributions are in focus, a low-numerical-aperture objective lens must be used, giving poor lateral resolution. Here this limitation is overcome using a 4Pi apparatus to produce the requisite two paths to the detector. The resulting instrument generalizes both SSM and 4Pi microscopy and allows a quantification of SSM resolution (rather than localization precision). Specifically, SSM is shown to be subject to the same resolution constraints as 4Pi microscopy.
© 2007 Optical Society of America
OCIS Codes
(100.3020) Image processing : Image reconstruction-restoration
(110.4850) Imaging systems : Optical transfer functions
(110.6880) Imaging systems : Three-dimensional image acquisition
(120.3180) Instrumentation, measurement, and metrology : Interferometry
(120.6200) Instrumentation, measurement, and metrology : Spectrometers and spectroscopic instrumentation
(170.2520) Medical optics and biotechnology : Fluorescence microscopy
ToC Category:
Instrumentation, Measurement, and Metrology
History
Original Manuscript: May 14, 2007
Revised Manuscript: October 3, 2007
Manuscript Accepted: October 3, 2007
Published: November 21, 2007
Virtual Issues
Vol. 3, Iss. 1 Virtual Journal for Biomedical Optics
Citation
Brynmor J. Davis, Mehmet Dogan, Bennett B. Goldberg, William C. Karl, M. Selim Ünlü, and Anna K. Swan, "4Pi spectral self-interference microscopy," J. Opt. Soc. Am. A 24, 3762-3771 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-24-12-3762
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