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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 6 — Jun. 13, 2007

Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging

Chad E. Bigelow, Nicusor V. Iftimia, R. Daniel Ferguson, Teoman E. Ustun, Benjamin Bloom, and Daniel X. Hammer  »View Author Affiliations


JOSA A, Vol. 24, Issue 5, pp. 1327-1336 (2007)
http://dx.doi.org/10.1364/JOSAA.24.001327


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Abstract

We have developed a compact, multimodal instrument for simultaneous acquisition of en face quasi-confocal fundus images and adaptive-optics (AO) spectral-domain optical coherence tomography (SDOCT) cross-sectional images. The optical system including all AO and SDOCT components occupies a 60 × 60 cm breadboard that can be readily transported for clinical applications. The AO component combines a Hartmann–Shack wavefront sensor and a microelectromechanical systems-based deformable mirror to sense and correct ocular aberrations at 15 Hz with a maximum stroke of 4 μ m . A broadband superluminescent diode source provides 4 μ m depth resolution for SDOCT imaging. In human volunteer testing, we observed up to an 8 dB increase in OCT signal and a corresponding lateral resolution of < 10 μ m as a result of AO correction.

© 2007 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(010.7350) Atmospheric and oceanic optics : Wave-front sensing
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Instrumentation and Techniques for Retinal Imaging

History
Original Manuscript: August 18, 2006
Revised Manuscript: October 25, 2006
Manuscript Accepted: November 6, 2006
Published: April 11, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Chad E. Bigelow, Nicusor V. Iftimia, R. Daniel Ferguson, Teoman E. Ustun, Benjamin Bloom, and Daniel X. Hammer, "Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging," J. Opt. Soc. Am. A 24, 1327-1336 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-24-5-1327

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