OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 6 — Jun. 13, 2007

Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging

Chad E. Bigelow, Nicusor V. Iftimia, R. Daniel Ferguson, Teoman E. Ustun, Benjamin Bloom, and Daniel X. Hammer  »View Author Affiliations


JOSA A, Vol. 24, Issue 5, pp. 1327-1336 (2007)
http://dx.doi.org/10.1364/JOSAA.24.001327


View Full Text Article

Enhanced HTML    Acrobat PDF (1097 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

We have developed a compact, multimodal instrument for simultaneous acquisition of en face quasi-confocal fundus images and adaptive-optics (AO) spectral-domain optical coherence tomography (SDOCT) cross-sectional images. The optical system including all AO and SDOCT components occupies a 60 × 60 cm breadboard that can be readily transported for clinical applications. The AO component combines a Hartmann–Shack wavefront sensor and a microelectromechanical systems-based deformable mirror to sense and correct ocular aberrations at 15 Hz with a maximum stroke of 4 μ m . A broadband superluminescent diode source provides 4 μ m depth resolution for SDOCT imaging. In human volunteer testing, we observed up to an 8 dB increase in OCT signal and a corresponding lateral resolution of < 10 μ m as a result of AO correction.

© 2007 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(010.7350) Atmospheric and oceanic optics : Wave-front sensing
(170.4470) Medical optics and biotechnology : Ophthalmology
(170.4500) Medical optics and biotechnology : Optical coherence tomography

ToC Category:
Instrumentation and Techniques for Retinal Imaging

History
Original Manuscript: August 18, 2006
Revised Manuscript: October 25, 2006
Manuscript Accepted: November 6, 2006
Published: April 11, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Chad E. Bigelow, Nicusor V. Iftimia, R. Daniel Ferguson, Teoman E. Ustun, Benjamin Bloom, and Daniel X. Hammer, "Compact multimodal adaptive-optics spectral-domain optical coherence tomography instrument for retinal imaging," J. Opt. Soc. Am. A 24, 1327-1336 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-24-5-1327


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. D. Huang, E. A. Swanson, C. P. Lin, J. S. Schuman, W. G. Stinson, W. Chang, M. R. Hee, T. Flotte, K. Gregory, C. A. Puliafito, and J. G. Fujimoto, "Optical coherence tomography," Science 254, 1178-1181 (1991). [CrossRef] [PubMed]
  2. C. A. Puliafito, M. R. Hee, J. S. Schuman, and J. G. Fujimoto, Optical Coherence Tomography of Ocular Diseases (Slack, 1996).
  3. D. Huang, P. K. Kaiser, C. Y. Lowder, and E. I. Traboulsi, Retinal Imaging (Mosby Elsevier, 2006).
  4. W. Drexler, U. Morgner, R. K. Ghanta, F. X. Kärtner, J. S. Schuman, and J. G. Fujimoto, "Ultrahigh-resolution ophthalmic optical coherence tomography," Nat. Med. 7, 502-507 (2001). [CrossRef] [PubMed]
  5. W. Drexler, U. Morgner, F. X. Kärtner, C. Pitrix, S. A. Boppart, X. D. Li, E. P. Ippen, and J. G. Fujimoto, "In vivo ultrahigh-resolution optical coherence tomography," Opt. Lett. 24, 1221-1223 (1999). [CrossRef]
  6. A. F. Fercher, C. K. Hitzenberger, G. Kamp, and S. Y. El-Zaiat, "Measurement of intraocular distances by backscattering spectral interferometry," Opt. Commun. 117, 43-48 (1995). [CrossRef]
  7. M. Wojtkowski, R. Leitgeb, A. Kowalczyk, T. Bajraszewski, and A. F. Fercher, "In vivo human retinal imaging by Fourier domain optical coherence tomography," J. Biomed. Opt. 7, 457-463 (2002). [CrossRef] [PubMed]
  8. N. Nassif, B. Cense, B. H. Park, S. H. Yun, T. C. Chen, B. E. Bouma, G. J. Tearney, and J. F. de Boer, "In vivo human retinal imaging by ultrahigh-speed spectral domain optical coherence tomography," Opt. Lett. 29, 480-482 (2004). [CrossRef] [PubMed]
  9. J. F. de Boer, B. Cense, B. H. Park, M. C. Pierce, G. J. Tearney, and B. E. Bouma, "Improved signal-to-noise ratio in spectral-domain compared with time-domain optical coherence tomography," Opt. Lett. 28, 2067-2069 (2003). [CrossRef] [PubMed]
  10. R. A. Leitgeb, C. K. Hitzenberger, and A. F. Fercher, "Performance of Fourier domain vs. time domain optical coherence tomography," Opt. Express 11, 889-894 (2003). [CrossRef] [PubMed]
  11. M. Choma, M. Sarunic, C. Yang, and J. Izatt, "Sensitivity advantage of swept source and Fourier domain optical coherence tomography," Opt. Express 11, 2183-2189 (2003). [CrossRef] [PubMed]
  12. A. W. Dreher, J. F. Bille, and R. N. Weinreb, "Active optical depth resolution improvement of the laser tomographic scanner," Appl. Opt. 28, 804-808 (1989). [CrossRef] [PubMed]
  13. J. Liang and D. R. Williams, "Aberrations and retinal image quality of the normal human eye,"J. Opt. Soc. Am. A 14, 2873-2883 (1997). [CrossRef]
  14. J. Liang, D. R. Williams, and D. T. Miller, "Supernormal vision and high-resolution retinal imaging through adaptive optics," J. Opt. Soc. Am. A 14, 2884-2892 (1997). [CrossRef]
  15. A. Roorda, F. Romero-Borja, W. I. Donnelly, H. Queener, T. Hebert, and M. Campbell, "Adaptive optics scanning laser ophthalmoscopy," Opt. Express 10, 405-412 (2002). [PubMed]
  16. B. Hermann, E. J. Fernandez, A. Unterhuber, H. Sattmann, A. F. Fercher, W. Drexler, P. M. Prieto, and P. Artal, "Adaptive-optics ultrahigh-resolution optical coherence tomography," Opt. Lett. 29, 2142-2144 (2004). [CrossRef] [PubMed]
  17. M. Pircher, B. Baumann, E. Gotzinger, and C. K. Hitzenberger, "Retinal cone mosaic imaged with transverse scanning optical coherence tomography," Opt. Lett. 31, 1821-1823 (2006). [CrossRef] [PubMed]
  18. R. J. Zawadzki, S. M. Jones, S. S. Olivier, M. Zhao, B. A. Bower, J. A. Izatt, S. Choi, S. Laut, and J. S. Werner, "Adaptive-optics optical coherence tomography for high-resolution and high-speed 3D retinal in vivo imaging," Opt. Express 13, 8532-8546 (2005). [CrossRef] [PubMed]
  19. Y. Zhang, B. Cense, J. Rha, R. S. Jonnal, W. Gao, R. J. Zawadzki, J. S. Werner, S. Jones, S. Olivier, and D. T. Miller, "High-speed volumetric imaging of cone photoreceptors with adaptive optics spectral-domain optical coherence tomography," Opt. Express 14, 4380-4394 (2006). [CrossRef] [PubMed]
  20. Y. Zhang, J. Rha, R. S. Jonnal, and D. T. Miller, "Adaptive optics parallel spectral domain optical coherence tomography for imaging the living retina," Opt. Express 13, 4792-4811 (2005). [CrossRef] [PubMed]
  21. D. X. Hammer, R. D. Ferguson, J. C. Magill, M. A. White, A. E. Elsner, and R. H. Webb, "Compact scanning laser ophthalmoscope with high-speed retinal tracker," Appl. Opt. 42, 4621-4632 (2003). [CrossRef]
  22. D. X. Hammer, R. D. Ferguson, T. E. Ustun, C. E. Bigelow, N. V. Iftimia, and R. H. Webb, "Line-scanning laser ophthalmoscope," J. Biomed. Opt. 11, 041126 (2006). [CrossRef]
  23. D. X. Hammer, R. D. Ferguson, J. C. Magill, M. A. White, A. E. Elsner, and R. H. Webb, "Image stabilization for scanning laser ophthalmoscopy," Opt. Express 10, 1542-1549 (2002).
  24. D. X. Hammer, R. D. Ferguson, C. E. Bigelow, N. V. Iftimia, T. E. Ustun, and S. A. Burns, "Adaptive optics scanning laser ophthalmoscope for stabilized retinal imaging," Opt. Express 14, 3354-3367 (2006). [CrossRef]
  25. L. N. Thibos, R. A. Applegate, J. T. Schwiegerling, and R. H. Webb, "Standards for reporting the optical aberrations of eyes," J. Refract. Surg. 18, S652-S660 (2002).
  26. E. Fernández and W. Drexler, "Influence of ocular chromatic aberration and pupil size on transverse resolution in ophthalmic adaptive optics optical coherence tomography," Opt. Express 13, 8184-8197 (2005). [CrossRef]
  27. E. J. Fernández, A. Unterhuber, B. Povazay, B. Hermann, P. Artal, and W. Drexler, "Chromatic aberration correction of the human eye for retinal imaging in the near infrared," Opt. Express 14, 6213-6225 (2006). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.


« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited