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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 6 — Jun. 13, 2007

Relating retinal nerve fiber thickness to behavioral sensitivity in patients with glaucoma: application of a linear model

Donald C. Hood  »View Author Affiliations

JOSA A, Vol. 24, Issue 5, pp. 1426-1430 (2007)

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Glaucoma causes damage to the retinal ganglion cells and their axons, and this damage can be detected with both structural and functional tests. The purpose of this study was to better understand the relationship between a structural measure of retinal nerve fiber layer (RNFL) and the most common functional test, behavioral sensitivity with static automated perimetry (SAP). First, a linear model, previously shown to describe the relationship between local visual evoked potentials and SAP sensitivity, was modified to predict the change in RNFL as measured by optical coherence tomography. Second, previous work by others was shown to be consistent with this model.

© 2007 Optical Society of America

OCIS Codes
(110.4500) Imaging systems : Optical coherence tomography
(330.4300) Vision, color, and visual optics : Vision system - noninvasive assessment
(330.5370) Vision, color, and visual optics : Physiological optics

ToC Category:
Clinical Applications of Retinal Imaging

Original Manuscript: July 31, 2006
Revised Manuscript: October 18, 2006
Manuscript Accepted: October 21, 2006
Published: April 11, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Donald C. Hood, "Relating retinal nerve fiber thickness to behavioral sensitivity in patients with glaucoma: application of a linear model," J. Opt. Soc. Am. A 24, 1426-1430 (2007)

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  1. D. C. Hood and V. C. Greenstein, "The multifocal VEP and ganglion cell damage: applications and limitations for the study of glaucoma," Prog. Retin. Eye Res. 22, 201-251 (2003). [CrossRef] [PubMed]
  2. H. A. Quigley, G. R. Dunkelberger, and W. R. Green, "Retinal ganglion cell atrophy correlated with automated perimetry in human eyes with glaucoma," Am. J. Ophthalmol. 107, 453-464 (1989). [PubMed]
  3. L. A. Kerrigan-Baumrind, H. A. Quigley, M. E. Pease, D. F. Kerrigan, and R. S. Mitchell, "Number of ganglion cells in glaucoma eyes compared with threshold visual field tests in the same persons," Invest. Ophthalmol. Visual Sci. 41, 741-748 (2000).
  4. R. S. Harwerth, L. Carter-Dawson, F. Shen, and E. L. Smith III, "Ganglion cell losses underlying visual field defects from glaucoma," Invest. Ophthalmol. Visual Sci. 40, 2242-2250 (1999).
  5. R. S. Harwerth, M. L. Crawford, L. J. Frishman, S. Viswanathan, E. L. Smith III, and L. Carter-Dawson, "Visual field defects and neural losses from experimental glaucoma," Prog. Retin. Eye Res. 21, 91-125 (2002). [CrossRef] [PubMed]
  6. R. S. Harwerth and H. A. Quigley, "Visual field defects and retinal ganglion cell losses in patients with glaucoma," Arch. Ophthalmol. (Chicago) 124, 853-859 (2006).
  7. D. F. Garway-Heath, A. Viswanathan, M. Westcott, D. Kamal, F. W. Fitzke, and R. A. Hitchings, "Relationship between perimetric light sensitivity and optic disk neuroretinal rim area," in Perimetry Update 1998/1999, M.Wall and J.M.Wild, eds. (Kugler, 1999), pp. 381-389.
  8. D. F. Garway-Heath, "Comparison of structural and functional methods--I," in Glaucoma Diagnosis. Structure and Function, R.N.Weinreb and E.L.Greve, eds. (Kugler, 2004), pp. 135-143.
  9. D. C. Hood, V. C. Greenstein, J. G. Odel, X. Zhang, R. Ritch, J. M. Liebmann, J. E. Hong, and C. S. Chen, and P. Thienprasiddhi, "Visual field defects and multifocal visual evoked potentials: evidence for a linear relationship," Arch. Ophthalmol. (Chicago) 120, 1672-1681 (2002).
  10. W. H. Swanson, J. Felius, and F. Pan, "Perimetric defects and ganglion cell damage: interpreting linear relations using a two-stage neural model," Invest. Ophthalmol. Visual Sci. 45, 466-472 (2004). [CrossRef]
  11. M. Shaf, A. B. Bernardes, J. A. Cardillo, R. A. Costa, L. A. S. Melo, J. C. Castro, and R. Varma, "Retinal nerve fibre layer thickness profile in normal eyes using third-generation optical coherence tomography," Eye 20, 431-439 (2006). [CrossRef]
  12. L. M. Zangwill, J. Williams, C. C. Berry, S. Knauer, and R. N. Weinreb, "A comparison of optical coherence tomography and retinal nerve fiber layer photography for detection of nerve fiber layer damage in glaucoma," Ophthalmologica 107, 1309-1315 (2000). [CrossRef]
  13. T. A. El Beltagi, C. Bowd, C. Boden, P. Amini, P. A. Sample, L. M. Zangwill, and R. N. Weinreb, "Retinal nerve fiber layer thickness measured with optical coherence tomography is related to visual function in glaucomatous eyes," Ophthalmologica 110, 2185-2191 (2003). [CrossRef]
  14. A. Kanamori, M. Nakamira, M. F. T. Escano, R. Seya, H. Maeda, and A. Negi, "Evaluation of the glaucomatous damage on retinal nerve fiber layer thickness measured by optical coherence tomography," Am. J. Ophthalmol. 135, 513-520 (2003). [CrossRef] [PubMed]
  15. C. K. Leung, W. H. Yung, A. C. Ng, J. Woo, M. K. Tsang, and K. K. Tse, "Evaluation of scanning resolution on retinal nerve fiber layer measurement using optical coherence tomography in normal and glaucomatous eyes," J. Process Control 13, 479-485 (2004).
  16. S. C. Anderson, J. D. Sinclair, M. Wall, C. Doyle, K. R. Woodward, C. Younger, and R. H. Kardon, "Correlation of regional visual field and retinal nerve fiber layer (OCT) in asymmetric glaucoma using either monocular vs. interocular difference analysis," presented at the Annual Meeting Abstract and Program Planner (Association for Research in Vision and Ophthalmology, 2006), Abstract 3673.
  17. R. Sihota, P. Sony, V. Gupta, T. Dada, and R. Singh, "Diagnostic capability of optical coherence tomography in evaluating the degree of glaucomatous retinal nerve fiber damage," Invest. Ophthalmol. Visual Sci. 47, 2006-2010 (2006). [CrossRef]
  18. T. E. Ogden, "Nerve fiber layer of the primate retina: thickness and glial content," Vision Res. 23, 581-587 (1983). [CrossRef] [PubMed]
  19. D. C. Hood and X. Zhang, "Multifocal ERG and VEP responses and visual fields: comparing disease-related changes," Doc. Ophthalmol. 100, 115-137 (2000). [CrossRef]
  20. D. C. Hood, V. C. Greenstein, K. Holopigian, R. Bauer, B. Firoz, J. M. Liebmann, J. G. Odel, and R. Ritch, "An attempt to detect glaucomatous damage to the inner retina with the multifocal ERG," Invest. Ophthalmol. Visual Sci. 41, 1570-1579 (2000).

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