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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 6 — Jun. 13, 2007

Imaging polarimetry and retinal blood vessel quantification at the epiretinal membrane

Masahiro Miura, Ann E. Elsner, Michael C. Cheney, Masahiko Usui, and Takuya Iwasaki  »View Author Affiliations

JOSA A, Vol. 24, Issue 5, pp. 1431-1437 (2007)

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We evaluated a polarimetry method to enhance retinal blood vessels masked by the epiretinal membrane. Depolarized light images were computed by removing the polarization retaining light reaching the instrument and were compared with parallel polarized light images, average reflectance images, and the corresponding images at 514 nm . Contrasts were computed for retinal vessel profiles for arteries and veins. Contrasts were higher in the 514 nm images in normal eyes but higher in the depolarized light image in the eyes with epiretinal membranes. Depolarized light images were useful for examining the retinal vasculature in the presence of retinal disease.

© 2007 Optical Society of America

OCIS Codes
(170.4470) Medical optics and biotechnology : Ophthalmology
(230.5440) Optical devices : Polarization-selective devices

ToC Category:
Clinical Applications of Retinal Imaging

Original Manuscript: July 27, 2006
Revised Manuscript: October 30, 2006
Manuscript Accepted: November 6, 2006
Published: April 11, 2007

Virtual Issues
Vol. 2, Iss. 6 Virtual Journal for Biomedical Optics

Masahiro Miura, Ann E. Elsner, Michael C. Cheney, Masahiko Usui, and Takuya Iwasaki, "Imaging polarimetry and retinal blood vessel quantification at the epiretinal membrane," J. Opt. Soc. Am. A 24, 1431-1437 (2007)

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  1. J. D. M. Gass, Stereoscopic Atlas of Macular Disease, 3rd ed. (Mosby, 1987).
  2. Y. Ogura and Y. Honda, "Evaluation of idiopathic epiretinal membranes by a scanning laser ophthalmoscope," Br. J. Ophthamol. 77, 534-535 (1993). [CrossRef]
  3. S. Rizzo, F. Genovesi-Ebert, S. Murri, C. Belting, A. Vento, F. Cresti, and M. L. Manca, "25-gauge, sutureless vitrectomy and standard 20-gauge pars plana vitrectomy in idiopathic epiretinal membrane surgery: a comparative pilot study," Graefe's Arch. Clin. Exp. Ophthalmol. 244, 472-479 (2006). [CrossRef]
  4. I. U. Scott, W. E. Smiddy, A. Merikansky, and W. Feuer, "Vitreoretinal surgery outcomes. Impact on bilateral visual function," Ophthalmology 104, 1041-1048 (1997).
  5. N. Patton, T. M. Aslam, T. MacGillivray, I. J. Deary, B. Dhillon, R. H. Eikelboom, K. Yogesan, and I. J. Constable, "Retinal image analysis: concepts, applications and potential," Prog. Retin Eye Res. 25, 99-127 (2006). [CrossRef]
  6. M. Hammer, S. Leistritz, L. Leistritz, and D. Schweitzer, "Light paths in retinal vessel oxymetry," IEEE Trans. Biomed. Eng. 48, 592-598 (2001). [CrossRef] [PubMed]
  7. R. Park, K. Twietmeyer, R. Chipman, N. Beaudry, andD. Salyer, "Wavelength dependence of the apparent diameter of retinal blood vessels," Appl. Opt. 44, 1831-1837 (2005). [CrossRef] [PubMed]
  8. F. C. Delori, E. S. Gragoudas, R. Francisco, and R. C. Pruett, "Monochromatic ophthalmoscopy and fundus photography. The normal fundus," Arch. Ophthalmol. (Chicago) 95, 861-868 (1977).
  9. A. E. Elsner, S. A. Burns, G. W. Hughes, and R. W. Webb, "Reflectometry with a scanning laser ophthalmoscope," Appl. Opt. 31, 3697-3710 (1992). [CrossRef] [PubMed]
  10. J. N. Kirkpatrick, A. Manivannan, A. K. Gupta, J. Hipwell, J. V. Forrester, and P. F. Sharp, "Fundus imaging in patients with cataract: role for a variable wavelength scanning laser ophthalmoscope," Br. J. Ophthamol. 79, 892-899 (1995). [CrossRef]
  11. A. E. Elsner, S. A. Burns, F. C. Delori, and R. H. Webb, "Quantitative reflectometry with the SLO," in Laser Scanning Ophthalmoscopy and Tomography, J.E.Nasemann and R.O. W.Burk, eds. (Quintessenz-Verlag, 1990), pp. 109-121.
  12. A. E. Elsner, S. Burns, J. Weiter, and F. Delori, "Infrared imaging of sub-retinal structures in the human ocular fundus," Vision Res. 36, 191-205 (1996). [CrossRef] [PubMed]
  13. D. U. Bartsch and W. R. Freeman, "Laser-tissue interaction and artifacts in confocal scanning laser ophthalmoscopy and tomography," Neurosci. Biobehav Rev. 17, 459-467 (1993). [CrossRef] [PubMed]
  14. A. Weber, M. C. Cheney, Q. Y. J. Smithwick, and A. E. Elsner, "Polarimetric imaging and blood vessel quantification," Opt. Express 12, 5178-5190 (2004). [CrossRef] [PubMed]
  15. M. Miura and A. E. Elsner, "Three-dimensional imaging in age-related macular degeneration," Opt. Express 9, 436-443 (2001). [CrossRef] [PubMed]
  16. S. A. Burns, A. E. Elsner, M. B. Mellem-Kairala, and R. B. Simmons, "Improved contrast of subretinal structures using polarization analysis," Invest. Ophthalmol. Visual Sci. 44, 4061-4068 (2003). [CrossRef]
  17. M. Miura, A. E. Elsner, A. Weber, M. C. Cheney, M. Osako, M. Usui, and T. Iwasaki, "Imaging polarimetry in central serous chorioretinopathy," Am. J. Ophthalmol. 140, 1014-1019 (2005). [CrossRef] [PubMed]
  18. M. B. Mellem-Kairala, A. E. Elsner, A. Weber, R. B. Simmons, and S. A. Burns, "Improved contrast of peripapillary hyperpigmentation using polarization analysis," Invest. Ophthalmol. Visual Sci. 46, 1099-1106 (2005). [CrossRef]
  19. A. E. Elsner, M. Miura, J. B. Stewart, M. B. Kairala, and S. A. Burns, "Novel algorithms for polarization imaging resulting in improved quantification of retinal blood vessels," Stud. Health Technol. Inform. 94, 59-61 (2003).
  20. A. W. Dreher, K. Reiter, and R. N. Weinreb, "Spatially resolved birefringence of the retinal nerve fiber layer assessed with a retinal laser ellipsometry," Appl. Opt. 31, 3730-3735 (1992). [CrossRef] [PubMed]
  21. S. G. Demos and R. R. Alfano, "Optical polarization imaging," Appl. Opt. 36, 150-155 (1997). [CrossRef] [PubMed]
  22. J. M. Bueno, "Polarimetry in the human eye using an imaging linear polariscope," J. Opt. A, Pure Appl. Opt. 4, 553-561 (2002). [CrossRef]
  23. R. A. Chipman, "Polarimetry," in Handbook of Optics, 2nd ed., M.Bass, ed. (McGraw-Hill, 1995), Vol. 2, pp. 1-28.
  24. Q. Zhou and R. N. Weinreb, "Individualized compensation of anterior segment birefringence during scanning laser polarimetry," Invest. Ophthalmol. Visual Sci. 43, 2221-2228 (2002).
  25. A. E. Elsner, L. Moraes, E. Beausencourt, A. Remky, J. Weiter, J. Walker, G. Wing, S. A. Burns, P. Raskauskas, and L. Kelley, "Scanning laser reflectometry of retinal and subretinal tissues," Opt. Express 6, 243-250 (2000). [CrossRef] [PubMed]
  26. M. Dogariu and T. Asakura, "Polarization-dependent backscattering patterns from weakly scattering media," J. Opt. (Paris) 24, 271-278 (1993). [CrossRef]
  27. J. S. Tyo, M. P. Rowe, E. N. Pugh, and N. Engheta, "Target detection in optically scattering media by polarization-difference imaging," Appl. Opt. 35, 1855-1870 (1996). [CrossRef] [PubMed]
  28. F. LeRoyBrehonnet, B. LeJeune, P. Y. Gerligand, J. Cariou, and J. Lotrian, "Analysis of depolarizing optical targets by Mueller matrix formalism," Pure Appl. Opt. 6, 385-404 (1997). [CrossRef]
  29. K. M. Yemelyanov, S. S. Lin, E. N. Pugh, Jr., and N. Engheta, "Adaptive algorithms for two-channel polarization sensing under various polarization statistics with nonuniform distributions," Appl. Opt. 45, 5504-5520 (2006). [CrossRef] [PubMed]

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