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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 2, Iss. 8 — Aug. 10, 2007

Quantitative spectrophotometry of scattering media via frequency-domain and constant-intensity measurements

John Crowe, David Morris, Malcolm Woolfson, Paul Rodmell, and John Walker  »View Author Affiliations


JOSA A, Vol. 24, Issue 7, pp. 1969-1974 (2007)
http://dx.doi.org/10.1364/JOSAA.24.001969


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Abstract

The attenuation of light by scattering and absorbing media is nonlinearly dependent upon the absorption coefficient, since detected light has experienced many different flight times. The frequency response of such a sample to modulated light is also nonlinear. We derive an expression for the attenuation that includes both the absorption coefficient and the modulation frequency. Its form is a power series whose coefficients are the cumulants of the temporal point-spread function (TPSF). Recasting this expression in terms of intensity leads to a similar expression with the cumulants replaced by the moments of the TPSF. A means of exploiting this relationship to produce estimates of the absolute concentration of the absorbing species is suggested.

© 2007 Optical Society of America

OCIS Codes
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.5270) Medical optics and biotechnology : Photon density waves
(290.7050) Scattering : Turbid media
(300.1030) Spectroscopy : Absorption

ToC Category:
Spectroscopy

History
Original Manuscript: September 1, 2006
Revised Manuscript: February 19, 2007
Manuscript Accepted: February 20, 2007
Published: June 13, 2007

Virtual Issues
Vol. 2, Iss. 8 Virtual Journal for Biomedical Optics

Citation
John Crowe, David Morris, Malcolm Woolfson, Paul Rodmell, and John Walker, "Quantitative spectrophotometry of scattering media via frequency-domain and constant-intensity measurements," J. Opt. Soc. Am. A 24, 1969-1974 (2007)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-24-7-1969


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