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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 2 — Feb. 10, 2009

Adaptive-optics imaging of human cone photoreceptor distribution

Toco YuenPing Chui, HongXin Song, and Stephen A. Burns  »View Author Affiliations

JOSA A, Vol. 25, Issue 12, pp. 3021-3029 (2008)

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We have used an adaptive-optics scanning laser ophthalmoscope to image the cone photoreceptor mosaic throughout the central 10°–12° of the retina for four normal subjects. We then constructed montages of the images and processed the montages to determine cone locations. Cone densities range from approximately 10,000 cones mm 2 at 7° to 40,000 cones mm 2 at 1°. The smallest cones were not resolved in the center of the fovea. From the locations of the cones we also analyzed the packing properties of the cone mosaic, finding that all four subjects had a slight cone streak of increased cone density and that, in agreement with previous studies using different approaches, the packing geometry decreased in regularity from the fovea toward the periphery. We also found variations in packing density between subjects and in local anisotropy across retinal locations. The complete montages are presented for download, as well as the estimated cone locations.

© 2008 Optical Society of America

OCIS Codes
(010.1080) Atmospheric and oceanic optics : Active or adaptive optics
(180.1790) Microscopy : Confocal microscopy
(330.5310) Vision, color, and visual optics : Vision - photoreceptors

ToC Category:
Vision, Color, and Visual Optics

Original Manuscript: July 29, 2008
Revised Manuscript: October 8, 2008
Manuscript Accepted: October 14, 2008
Published: November 19, 2008

Virtual Issues
Vol. 4, Iss. 2 Virtual Journal for Biomedical Optics
Interactive Science Publishing (2008) Optics Express

Toco Yuen Chui, HongXin Song, and Stephen A. Burns, "Adaptive-optics imaging of human cone photoreceptor distribution," J. Opt. Soc. Am. A 25, 3021-3029 (2008)

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