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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 3, Iss. 4 — Apr. 23, 2008

Imaging interferometric microscopy

Yuliya Kuznetsova, Alexander Neumann, and Steven R.J. Brueck  »View Author Affiliations


JOSA A, Vol. 25, Issue 3, pp. 811-822 (2008)
http://dx.doi.org/10.1364/JOSAA.25.000811


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Abstract

Imaging interferometric microscopy (IIM) is a synthetic aperture imaging approach providing resolution to the transmission medium (refractive index n) linear systems limit extending to λ 4 n using only low-numerical-aperture (low- NA ) optics. IIM uses off-axis illumination to access high spatial frequencies along with interferometric reintroduction of a zero-order reference beam on the low- NA side of the optical system. For a thin object normal to the optical axis, the frequency space limit is [ ( 1 + NA ) n λ ] , while tilting the object plane allows collection of diffraction information up to the material transmission bandpass-limited spatial frequency of 2 n λ . Tilting transforms the spatial frequencies; the algorithm to reset to the correct image frequencies is described. IIM involves combining multiple subimages; the image reconstruction procedures are discussed. A mean-square-error metric is introduced. For binary objects, sigmoidal filtering of the image provides significant resolution improvement.

© 2008 Optical Society of America

OCIS Codes
(180.0180) Microscopy : Microscopy
(180.3170) Microscopy : Interference microscopy
(110.3175) Imaging systems : Interferometric imaging

ToC Category:
Microscopy

History
Original Manuscript: September 13, 2007
Revised Manuscript: January 9, 2008
Manuscript Accepted: January 10, 2008
Published: February 25, 2008

Virtual Issues
Vol. 3, Iss. 4 Virtual Journal for Biomedical Optics

Citation
Yuliya Kuznetsova, Alexander Neumann, and Steven R. J. Brueck, "Imaging interferometric microscopy," J. Opt. Soc. Am. A 25, 811-822 (2008)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-25-3-811

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