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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 5 — May. 5, 2009

Forward-calculated analytical interferograms in pass-through photon-based biomedical transillumination

Paulino Vacas-Jacques, Marija Strojnik, and Gonzalo Paez  »View Author Affiliations


JOSA A, Vol. 26, Issue 3, pp. 602-612 (2009)
http://dx.doi.org/10.1364/JOSAA.26.000602


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Abstract

Recently, we have introduced a transillumination technique for biomedical diagnosis. The technique, pass-through photon-based transillumination, relies on interferometric measurements to recover the information of interest. In this work, we present the forward-calculated analytical interferograms that describe the behavior of the system. Stochastic modeling of radiation interacting with tissue enables determination of amplitude and phase parameters, indispensable for computation of the interferograms. Sample variability is assessed by studying tissue phantoms similar to those used in the experimental verification of the technique and that are representative of (abnormal) dental tissues. For tissue characterization, perfect recovery of the integrated attenuation ensues by employing spatially compact radiation sources. For tissue imaging, spatially extended sources with broad bandwidth are superior due to the implicit longitudinal coherence filter. For both applications, sample variability issues may be neutralized by permitting spatial divergence of scattered photons.

© 2009 Optical Society of America

OCIS Codes
(170.1650) Medical optics and biotechnology : Coherence imaging
(170.3660) Medical optics and biotechnology : Light propagation in tissues
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.6935) Medical optics and biotechnology : Tissue characterization

ToC Category:
Medical Optics and Biotechnology

History
Original Manuscript: July 18, 2008
Revised Manuscript: December 8, 2008
Manuscript Accepted: December 9, 2008
Published: February 20, 2009

Virtual Issues
Vol. 4, Iss. 5 Virtual Journal for Biomedical Optics

Citation
Paulino Vacas-Jacques, Marija Strojnik, and Gonzalo Paez, "Forward-calculated analytical interferograms in pass-through photon-based biomedical transillumination," J. Opt. Soc. Am. A 26, 602-612 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-26-3-602

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