Hybrid imaging systems combining x-ray computed tomography (CT) and fluorescence tomography can improve fluorescence imaging performance by incorporating anatomical x-ray CT information into the optical inversion problem. While the use of image priors has been investigated in the past, little is known about the optimal use of forward photon propagation models in hybrid optical systems. In this paper, we explore the impact on reconstruction accuracy of the use of propagation models of varying complexity, specifically in the context of these hybrid imaging systems where significant structural information is known a priori. Our results demonstrate that the use of generically known parameters provides near optimal performance, even when parameter mismatch remains.
© 2009 Optical Society of America
Original Manuscript: September 9, 2008
Revised Manuscript: January 5, 2009
Manuscript Accepted: January 19, 2009
Published: March 20, 2009
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics
Damon Hyde, Ralf Schulz, Dana Brooks, Eric Miller, and Vasilis Ntziachristos, "Performance dependence of hybrid x-ray computed tomography/fluorescence molecular tomography on the optical forward problem," J. Opt. Soc. Am. A 26, 919-923 (2009)