OSA's Digital Library

Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics

| EXPLORING THE INTERFACE OF LIGHT AND BIOMEDICINE

  • Editor: Gregory W. Faris
  • Vol. 4, Iss. 6 — May. 26, 2009

Performance dependence of hybrid x-ray computed tomography/fluorescence molecular tomography on the optical forward problem

Damon Hyde, Ralf Schulz, Dana Brooks, Eric Miller, and Vasilis Ntziachristos  »View Author Affiliations


JOSA A, Vol. 26, Issue 4, pp. 919-923 (2009)
http://dx.doi.org/10.1364/JOSAA.26.000919


View Full Text Article

Enhanced HTML    Acrobat PDF (160 KB)





Browse Journals / Lookup Meetings

Browse by Journal and Year


   


Lookup Conference Papers

Close Browse Journals / Lookup Meetings

Article Tools

Share
Citations

Abstract

Hybrid imaging systems combining x-ray computed tomography (CT) and fluorescence tomography can improve fluorescence imaging performance by incorporating anatomical x-ray CT information into the optical inversion problem. While the use of image priors has been investigated in the past, little is known about the optimal use of forward photon propagation models in hybrid optical systems. In this paper, we explore the impact on reconstruction accuracy of the use of propagation models of varying complexity, specifically in the context of these hybrid imaging systems where significant structural information is known a priori. Our results demonstrate that the use of generically known parameters provides near optimal performance, even when parameter mismatch remains.

© 2009 Optical Society of America

OCIS Codes
(110.0113) Imaging systems : Imaging through turbid media
(110.1758) Imaging systems : Computational imaging

ToC Category:
Imaging Systems

History
Original Manuscript: September 9, 2008
Revised Manuscript: January 5, 2009
Manuscript Accepted: January 19, 2009
Published: March 20, 2009

Virtual Issues
Vol. 4, Iss. 6 Virtual Journal for Biomedical Optics

Citation
Damon Hyde, Ralf Schulz, Dana Brooks, Eric Miller, and Vasilis Ntziachristos, "Performance dependence of hybrid x-ray computed tomography/fluorescence molecular tomography on the optical forward problem," J. Opt. Soc. Am. A 26, 919-923 (2009)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-26-4-919


Sort:  Author  |  Year  |  Journal  |  Reset  

References

  1. V. Ntziachristos, A. G. Yodh, M. Schnall, and B. Chance, “Concurrent MRI and diffuse optical tomography of breast after indocyanine green enhancement,” Proc. Natl. Acad. Sci. U.S.A. 97, 2767-2772 (2000). [CrossRef] [PubMed]
  2. A. Joshi, W. Bangerth, and E. M. Sevick-Muraca, “Non-contact fluorescence optical tomography with scanning patterned illumination,” Opt. Express 14, 6516-6534 (2006). [CrossRef] [PubMed]
  3. S. C. Davis, H. Dehghani, J. Wang, S. Jiang, B. W. Pogue, and K. D. Paulsen, “Image-guided diffuse optical fluorescence tomography implemented with Laplacian-type regularization,” Opt. Express 15, 4066-4082 (2007). [CrossRef] [PubMed]
  4. V. Ntziachristos, E. A. Schellenberger, J. Ripoll, D. Yessayan, E. Graves, J. Alexi Bogdanov, L. Josephson, and R. Weissleder, “Visualization of antitumor treatment by means of fluorescence molecular tomography with an annexin V-Cy5.5 conjugate,” Proc. Natl. Acad. Sci. U.S.A. 101, 12294-12299 (2004). [CrossRef] [PubMed]
  5. R. Barbour, S. Barbour, P. Koo, H. L. Graber, R. Aronson, and J. Chang, “MRI-guided optical tomography: Prospects and computation for a new imaging method,” IEEE Comput. Sci. Eng. 2, 63-77 (1995). [CrossRef]
  6. B. Brooksby, S. Jiang, C. Kogel, M. Doyley, H. Dehghani, J. Weaver, S. Poplack, B. Pogue, and K. Paulsen, “Magnetic resonance guided near infrared tomography of the breast,” Rev. Sci. Instrum. 75, 5262-5270 (2004). [CrossRef]
  7. P. K. Yalavarthy, B. W. Pogue, H. Dehghani, and K. D. Paulsen, “Weight-matrix structured regularization provides optimal generalized least-squares estimate in diffuse optical tomography,” Med. Phys. 34, 2085-2098 (2007). [CrossRef] [PubMed]
  8. M. Guven, B. Yazici, X. Intes, and B. Chance, “Diffuse optical tomography with a priori anatomical information,” Phys. Med. Biol. 50, 2837-2858 (2005). [CrossRef] [PubMed]
  9. V. Ntziachristos and R. Weissleder, “Experimental three-dimensional fluorescence reconstruction of diffuse media by use of the normalized Born approximation,” Opt. Lett. 26, 893-895 (2001). [CrossRef]
  10. A. Soubret, J. Ripoll, and V. Ntziachristos, “Accuracy of fluorescent tomography in the presence of heterogeneities: Study of the normalized Born ratio,” IEEE Trans. Med. Imaging 24, 1377-1386 (2005). [CrossRef] [PubMed]
  11. T. Lasser, A. Soubret, J. Ripoll, and V. Ntziachristos, “Surface reconstruction for free-space 360° fluorescence molecular tomography and the effects of animal motion,” IEEE Trans. Med. Imaging 27, 188-194 (2008). [CrossRef] [PubMed]
  12. A. B. Milstein, J. J. Stott, S. Oh, D. A. Boas, R. P. Millane, C. A. Bouman, and K. J. Webb, “Fluorescence optical diffusion tomography using multiple-frequency data,” J. Opt. Soc. Am. A 21, 1035-1049 (2004). [CrossRef]
  13. W. Bangerth, R. Hartmann, and G. Kanschat, “Deal.II--a general-purpose object-oriented finite element library,” ACM Trans. Math. Softw. 33, 24:1-24:27 (2007). [CrossRef]
  14. W. Bangerth, R. Hartmann, and G. Kanschat, Deal.II: A Finite Element Differential Equations Analysis Library, http://www.dealii.org.
  15. C. Paige and M. Saunders, “LSQR: An algorithm for sparse linear equations and sparse least squares,” ACM Trans. Math. Softw. 8, 43-71 (1982). [CrossRef]

Cited By

Alert me when this paper is cited

OSA is able to provide readers links to articles that cite this paper by participating in CrossRef's Cited-By Linking service. CrossRef includes content from more than 3000 publishers and societies. In addition to listing OSA journal articles that cite this paper, citing articles from other participating publishers will also be listed.

Figures

Fig. 1 Fig. 2 Fig. 3
 
Fig. 4
 

« Previous Article  |  Next Article »

OSA is a member of CrossRef.

CrossCheck Deposited