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Virtual Journal for Biomedical Optics

Virtual Journal for Biomedical Optics


  • Editors: Andrew Dunn and Anthony Durkin
  • Vol. 6, Iss. 1 — Jan. 3, 2011

Optoacoustic tomography with varying illumination and non-uniform detection patterns

Thomas Jetzfellner, Amir Rosenthal, Andreas Buehler, Alexander Dima, Karl-Hans Englmeier, Vasilis Ntziachristos, and Daniel Razansky  »View Author Affiliations

JOSA A, Vol. 27, Issue 11, pp. 2488-2495 (2010)

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Quantification of tissue morphology and biomarker distribution by means of optoacoustic tomography is an important and longstanding challenge, mainly caused by the complex heterogeneous structure of biological tissues as well as the lack of accurate and robust reconstruction algorithms. The recently introduced model-based inversion approaches were shown to mitigate some of reconstruction artifacts associated with the commonly used back-projection schemes, while providing an excellent platform for obtaining quantified maps of optical energy deposition in experimental configurations of various complexity. In this work, we introduce a weighted model-based approach, capable of overcoming reconstruction challenges caused by per-projection variations of object’s illumination and other partial illumination effects. The universal weighting procedure is equally shown to reduce reconstruction artifacts associated with other experimental imperfections, such as non-uniform transducer sensitivity fields. Significant improvements in image fidelity and quantification are showcased both numerically and experimentally on tissue phantoms and mice.

© 2010 Optical Society of America

OCIS Codes
(170.3010) Medical optics and biotechnology : Image reconstruction techniques
(170.3880) Medical optics and biotechnology : Medical and biological imaging
(170.5120) Medical optics and biotechnology : Photoacoustic imaging

ToC Category:
Medical Optics and Biotechnology

Original Manuscript: July 19, 2010
Revised Manuscript: September 16, 2010
Manuscript Accepted: September 17, 2010
Published: October 27, 2010

Virtual Issues
Vol. 6, Iss. 1 Virtual Journal for Biomedical Optics

Thomas Jetzfellner, Amir Rosenthal, Andreas Buehler, Alexander Dima, Karl-Hans Englmeier, Vasilis Ntziachristos, and Daniel Razansky, "Optoacoustic tomography with varying illumination and non-uniform detection patterns," J. Opt. Soc. Am. A 27, 2488-2495 (2010)

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