Optomechanical imaging system for breast cancer detection

Rabah Al abdi; Harry L. Graber; Yong Xu; Randall L. Barbour

doi:10.1364/JOSAA.28.002473

Journal of the Optical Society of America A
Vol. 28,
Issue 12,
pp. 2473-2493
(2011)
•https://doi.org/10.1364/JOSAA.28.002473

Optomechanical imaging system for breast cancer detection

Rabah Al abdi, Harry L. Graber, Yong Xu, and Randall L. Barbour

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Rabah Al abdi, Harry L. Graber, Yong Xu, and Randall L. Barbour, "Optomechanical imaging system for breast cancer detection," J. Opt. Soc. Am. A 28, 2473-2493 (2011)

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Table of Contents Category
- Medical Optics and Biotechnology
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About this Article
History
- Original Manuscript: April 8, 2011
- Revised Manuscript: September 2, 2011
- Manuscript Accepted: September 6, 2011
- Published: November 11, 2011
Virtual Issues
Virtual Journal for Biomedical Optics Vol. 7, Iss. 2

Abstract

Imaging studies of the breast comprise three principal sensing domains: structural, mechanical, and functional. Combinations of these domains can yield either additive or wholly new information, depending on whether one domain interacts with the other. In this report, we describe a new approach to breast imaging based on the interaction between controlled applied mechanical force and tissue hemodynamics. Presented is a description of the system design, performance characteristics, and representative clinical findings for a second-generation dynamic near-infrared optical tomographic breast imager that examines both breasts simultaneously, under conditions of rest and controlled mechanical provocation. The expected capabilities and limitations of the developed system are described in relation to the various sensing domains for breast imaging.

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Type	Parameter	Value
Optical	Wavelengths	760 and $830 nm$
	Number of Sources	64 (32 left and 32 right)
	Number of Detectors	128 (64 left and 64 right)
	Detector Sensitivity	$10 pW$
	Dynamic Range	$1 ∶ 10^{9}$ ( $180 dB$ )
	Cross Talk (Optical)	$< 1 ∶ 10^{- 5}$
	Cross Talk (Electronic)	$< 1 ∶ 10^{- 6}$
	Long-Term Stability ( $40 \min$ )	CV $< 0.3 %$ up to gain $10^{5}$ , CV $< 2 %$ at gain $10^{6}$
	Dark Noise	$< 1 mV$ , up to gain $10^{5}$ , $< 7 mV$ , at gain $10^{6}$
	Optical Data Acquisition Rate	$1.8 Hz$ for 8192 channels

Mechanical	Force Sensitivity	$0.04 N$ ( $0.01 lb$ )
	Capacity	$15 N$ ( $3.4 lb$ )
	Cross Talk (Force)	$1 ∶ 10^{- 3}$
	Repeatability (STD)^a	$0.08 N$ ( $0.02 lb$ )
	Articulation Range	$90 mm$
	Articulation Speed	$4.8 mm / s$
	Mechanical Data Acquisition Rate	$20 Hz$ for 16 channels

	$μ_{a 760}$		$μ_{a 830}$
Condition	$(x - x_{0}, y - y_{0}, z - z_{0})$	ρ	$(x - x_{0}, y - y_{0}, z - z_{0})$	ρ
Baseline	$(0, 3, - 3)$	0.97	$(0, 1, - 3)$	0.99
Full Compression	$(0, 0, - 3)$	0.94	$(0, - 1, - 3)$	0.96
ML Relaxation	$(- 1, 0, - 3)$	0.95	$(- 1, - 2, - 3)$	0.95
CC Relaxation	$(0, 0, - 3)$	0.94	$(- 1, - 1, - 3)$	0.98
ML Compression	$(1, 0, - 4)$	0.92	$(2, - 2, - 5)$	0.97

	$μ_{a 830}$
Condition	$(x - x_{0}, y - y_{0}, z - z_{0})$	ρ
$750 ml$ , $1 vol. %$ Intralipid^a	$(0, + 1, - 3)$	0.99
$750 ml$ , $1 vol. %$ Intralipid with India Ink	$(+ 2, 0, - 2)$	0.97
$1250 ml$ , $1 vol. %$ Intralipid	$(0, + 2, 0)$	0.96
$1250 ml$ , $1 vol. %$ Intralipid with India Ink	$(+ 2, + 1, - 2)$	0.94

		Orientation of Articulating Elements
		Lateral		Craniocaudal				Medial
Parameter		AU1^a	AU2	AU3	AU4	AU5	AU6	AU7	AU8
Healthy Breast	Stiffness (kPa)	1.4	2.4	2.3	2.5	2.3	1.9	2.1	2.9
Healthy Breast	Standard error	0.3	0.4	0.4	0.4	0.3	0.2	0.4	0.3
Tumor Breast	Stiffness (kPa)	1.7 ^b	2.1	2.2	2.3	2.4	2.4 ^b	2.8 ^b	3.5 ^b
Tumor Breast	Standard error	0.3	0.2	0.4	0.3	0.4	0.3	0.3	0.2

Parameter	$7.1 N$ Compression	Arms Motion	Speaking	Leg Motion	Head Motion	Baseline
Range of Change (%)	100	13.1	12.1	7.7	7.7	5.8
Standard Deviation	4.2	2.4	3.9	1.9	1.5	1.0

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Journal of the Optical Society of America A