|
Information loss and reconstruction in diffuse fluorescence tomography |
JOSA A, Vol. 29, Issue 3, pp. 321-330 (2012)
http://dx.doi.org/10.1364/JOSAA.29.000321
Enhanced HTML 
Acrobat PDF (381 KB)
Abstract
This paper is a theoretical exploration of spatial resolution in diffuse fluorescence tomography. It is demonstrated that, given a fixed imaging geometry, one cannot—relative to standard techniques such as Tikhonov regularization and truncated singular value decomposition—improve the spatial resolution of the optical reconstructions via increasing the node density of the mesh considered for modeling light transport. Using techniques from linear algebra, it is shown that, as one increases the number of nodes beyond the number of measurements, information is lost by the forward model. It is demonstrated that this information cannot be recovered using various common reconstruction techniques. Evidence is provided showing that this phenomenon is related to the smoothing properties of the elliptic forward model that is used in the diffusion approximation to light transport in tissue. This argues for reconstruction techniques that are sensitive to boundaries, such as
© 2012 Optical Society of America
OCIS Codes
(100.6950) Image processing : Tomographic image processing
(110.6960) Imaging systems : Tomography
(110.7050) Imaging systems : Turbid media
(110.3010) Imaging systems : Image reconstruction techniques
ToC Category:
Imaging Systems
History
Original Manuscript: September 2, 2011
Revised Manuscript: November 16, 2011
Manuscript Accepted: December 2, 2011
Published: February 17, 2012
Virtual Issues
Vol. 7, Iss. 5 Virtual Journal for Biomedical Optics
Citation
Petra Bonfert-Taylor, Frederic Leblond, Robert W. Holt, Kenneth Tichauer, Brian W. Pogue, and Edward C. Taylor, "Information loss and reconstruction in diffuse fluorescence tomography," J. Opt. Soc. Am. A 29, 321-330 (2012)
http://www.opticsinfobase.org/vjbo/abstract.cfm?URI=josaa-29-3-321
You do not have subscription access to this journal. Citation lists with outbound citation links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Cited by links are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Figure files are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
You do not have subscription access to this journal. Article level metrics are available to subscribers only. You may subscribe either as an OSA member, or as an authorized user of your institution.
Contact your librarian or system administrator
or
Log in to access OSA Member Subscription
Related Journal Articles 
- Visualization of foreign atoms by optical magnetic-resonance imaging of Cs atoms (JOSAB)
- Tomographic scanning imager (OE)
- Improved 2D vector field estimation using probabilistic weights (JOSAA)
- Beating the wavelength limit: three-dimensional imaging of buried subwavelength fractures in sculpture and construction materials by terahertz time-domain reflection spectroscopy (AO)
- Construction and demonstration of a multispectral tomographic scanning imager (TOSCA) (OE)
Related Conference Papers
« Previous Article | Next Article »
OSA is a member of 